Antitumor cytotoxicity

China Menispermum dauricum L. Acutumine, acutuminine, dauricine, disinomenine, magnoflorine, menispermine, sinomenine, stepharine, tetrandrine.50 Antitumor, cytotoxic, alleviate skin allergies, antirheumatic, anticancer against esophageal cancer. 

We and others have demonstrated facile synthesis of a number of new anticancer active p-lactams. The p-lactam derivatives described herein are unique, and they demonstrate reasonable in vitro antitumor cytotoxicity. The stereochemical outcome of the Staudinger reaction as reported herein may offer our laboratory and others many additional opportunities to use p-lactams in the synthesis of biologically active compounds. Although the mechanism of action of the lead compounds has not been totally established, our research on cell cycle analysis offers intriguing... 

Nanaomycin A (128), an antibiotic pyranonaphthoquinone, has been synthesized via this route starting from (127). This method has also been applied to the synthesis of royleanone (129), an abietanoid diteipene quinone possessing antitumor cytotoxicity, in which the highly substituted quinone skeleton has been efficiently constmcted by using the maleoylcobalt complex. ... 

Castitteja linariaefoUa Isoverbascoside Verbascoside Antitumoral Cytotoxic activity against P-388 Active Active [68]... 

Scrophulario albidci Antitumoral Cytotoxic activity against dRLh-84 S-180 P-388/DI HeLa [32]... 

Antitumoral Cytotoxic activity against HeLa, Vero and BHK.-21 [91]... 

Actions Antiseptic, antibacterial, antihemorrhagic, antifungal, antiamebic, astringent, expectorant, diaphoretic, mucosal anti-inflammatory, mucosal stimulant, mucosal tonic, antitumor (cytotoxic). 

Gitlerman CO (1965) Antitumor, Cytotoxic, and Antibacterial Activities of Tenuazonic Acid and Congeneric Tetramic Adds. J Med Chem 8 483... 

ANTITUMOR CYTOTOXICITY The stabilization effect of benzaldehyde by a-cyclodextrin is also reflected in the in vitro antitumor cytotoxicity against human tumor cell lines A-549 (non-small-cell lung carcinoma), MCF-7 (breast adenocarcinoma) and HT-29 (colon adenocarcinoma) (Table III). a-Cyclodextrin-benzaldehyde inclusion complex is about 5-8 fold more cytotoxic than ftee ben dehyde. 

Table m. In vitro antitumor cytotoxicity against human tumor cell lines... 

Jicha DL, Mule JJ, Rosenberg SA. Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy. JExpMed 1991 174 1511-1515. 

---