DNA-damaging activity

Bartoli S, Bonora B, Colacci A, et al. 1991. DNA damaging activity of methyl parathion. Res Commun Chem Pathol Pharmacol 71 209-218. 

Parodi, S., S.DeFlora, M.Cavanna, and others. 1981. DNA-damaging activity in vivo and bacterial mutagenicity of sixteen hydrazine derivatives as related quantitatively to their carcinogenicity. Cancer Res. 41 1469-1482. 

Kada, T. (1981). The DNA damaging activity of 42 coded compounds in the Rec-assay. In Evaluation of Short-term Tests for Carcinogens. Report of the International Collaborative Program (de Serres F. and Ashby J., Eds.). Elsevier/North Holland, Amsterdam, pp. 175— 182. 

Abstract Over 200 plant extracts were prepared from different family plants of rich flora of Turkey, in a frame of international collaborative project Bioactive Turkish Plant Constitnents . The plants were chosen randomly and/or partly based on their folkloric uses which belonged to 40 distinct families growing in Aegean and Marmara region, and their extracts were screened for their DNA damaging activity as well as for their human ovarian cytotoxic activity. 

Since DNA damaging activity resnlts didn t give almost no hit except a few extracts Ajuga and Juniperus) (Table 6.4) we directed onr bioactivity assay to ovarian cytotoxic activity search. 

Shiau SY, Huff RA, Wells BC, et al. 1980. Mutagenicity and DNA-damaging activity for several pesticides tested with Bacillus subtilis mutants. Mutat Res 71 169-179. 

Sakaguchi K, Herrera JE, Saito S, Mild T, Bustin M, Vassilev A, Anderson CW, Appella E (1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 12( 18) 2831-2841 Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (2000). Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol 20(23) 8933-8943... 

Goren, A. C., Zhou, B.-N. and Kingston, D. G. I. 2003. Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei. Planta Medica, 69 867-868. 

Kawai, K. (1998) Enhancement of the DNA damaging activity of A -nitrosodimethylamine by di-(2-ethylhexyl)phthalate in somatic cells in vivo of Drosophila melanogaster. Biol, pharm. Bull, 21, 579-582... 

Figure 11.4 DNA damage activity (expressed as tail moment) in blood of juvenile pink snapper exposed to the selected SBMs Syndrill 80 20 and Syndrill 80 20 (Mod) for 21 days. Indicates a significant difference (p < 0.05) from negative control fish.

Kada, T. (1981) The DNA-damaging activity of 42 coded compounds in the Rec-assay. In de... 

Organotin complexes of di(2-pyridyl) ketone 2-thenoylhydrazone, 1 and 2, with 6- and 5-coordinated tin atom are less active than the parent organotins67,68. Compound 2 showed good results in tests against Bacillus subtilis, Staphylococcus aureus and also toward several Bacilli with minimum inhibitory concentration ranging from 1.5 to 3 pgml-167. At the same time this complex is devoid of DNA-damaging activity in the Bacillus subtilis rec-... 

Sauter, M. and Adam, W. (1995) Oxyfunctionalization of benzofurans by singlet oxygen, dioxiranes, and peracids chemical model studies for the DNA-damaging activity of benzofuran dioxetanes (oxidation) and epoxides (alkylation). Accounts of Chemical Research, 28 (7), 289-298. 

The question of oxidative cyclization versus a polyepoxide cascade in the biosynthesis of polyether natural products has been reviewed <1995AGE298>. Enzymatic domino reactions involving epoxide intermediates have been reviewed <2001CSR332>. The DNA-damaging activity of epoxides and other oxidized species has been examined using chemical models <1995ACR289>. 

Sauter and Adam have applied DMDO lb for the epoxidation of benzofurans in their study of the DNA-damaging activity of benzofuran epoxides 70 and their valence-isomeric compounds 71 and 72 <1995ACR289>. 

T, Sehested M, Lukas J, Bartek J. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res. 2001 61 4990-4993. Ahn JY, Li X, Davis HL, Canman CE. Phosphorylation of threonine 68 promotes oUgomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain. J. Biol. Chem. 2002 277 19389-19395. 

Bakkenist CJ, Kastan MB. DNA damage activates ATM through 34. intermolecular autophosphorylation and dimer dissociation. Nature 2003 421(6922) 499-506. 

The silatecan (DB-67) (21) represents a new generation of camptothecin derivatives (see Table 12) that exhibits a potent in vitro DNA topoisomerase I (TOPl)-mediated DNA-damaging activity, improved blood stability, and holds significant promise for the treatment of human cancers [79]. This new agent was found to be 25-times more lipophilic than camptothecin it incorporates readily into cellular and liposomal bilayers. In addition, its 10-hydroxy functionality enhances drug stability in the presence of human serum albumin. Thus, the net... 

The nonnutritive sweeteners acesulfame-K, aspartame, cyclamate, saccharin, and sucralose were tested for DNA damaging activity in the rat hepatocyte/ DNA repair assay using hepatocytes from rats. The results found no evidence of genotoxic potential. 

Jeffrey AM and Williams GM (2000) Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay. Pood and Chemical Toxicology 38 335-338. 

Carbaryl inhibited neurite outgrowth in N2a cells in vitro. Carbaryl also exhibited DNA-damaging activity in a human lymphoblastoid cell line and human liver HepG2 cells. 

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