Forkhead-associated domain

T, Sehested M, Lukas J, Bartek J. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res. 2001 61 4990-4993. Ahn JY, Li X, Davis HL, Canman CE. Phosphorylation of threonine 68 promotes oUgomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain. J. Biol. Chem. 2002 277 19389-19395. 

Signal Transmission via Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity Forkhead-associated Domains... 

Forkhead-associated domains (FHA domains) were originally identified as conserved sequence elements within a subset of forkhead transcription factors and were subsequently found, e. g., in other transcription factors, in protein kinases, protein phosphatases, and kinesin motors (review Durocher and Jackson, 2002). FHA domains comprise up to 140 amino acids, exhibit binding specificity toward phosphothreonine residues, and efficiently discriminate against phosphoserine residues. 

Cerosaletti, K. M., and Concannon, P. (2003). Nibrtn forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation./. Biol. Chem. 278, 21944—21951. 

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