CREB binding protein

Cytokines such as TNFa and IL-1 3, acting via NF-kB, can induce histone acetylation in both a time- and concentration-dependent manner. Upon DNA binding, NF-kB recruits transcriptional coactivators such as CREB binding protein (CBP) and p300/CBP-associated factor (PCAF). 

Chromatin remodeling, transcription factor modification by various enzyme activities, and the communication between the nuclear receptors and the basal transcription apparatus are accomplished by protein-protein interactions with one or more of a class of coregulator molecules. The number of these coregulator molecules now exceeds 100, not counting species variations and splice variants. The first of these to be described was the CREB-binding protein, CBP. CBP, through an amino terminal domain, binds to phosphorylated serine 137 of CREB and mediates transactivation in response to cAMP. It thus is described as a coactivator. CBP and... 

Marzio G, Tyagi M, Gutierrez MI, Giacca M (1998) HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter. Proc Natl Acad Sd USA95(23) 13519-13524... 

The detailed mechanisms involved in CREB phosphorylation were first established for the cAMP pathway. A first messenger that increases cAMP concentrations leads to activation of PKA and to translocation of the free catalytic subunit of the protein kinase into the nucleus, where it phosphorylates CREB on serine 133. Such phosphorylation then promotes the binding of CREB to a CREB-binding protein (CBP). CBP, upon binding CREB, interacts directly with the RNA polymerase II complex, which mediates the initiation of transcription. In most cases, such interactions lead to the activation of transcription, although it is possible that the expression of some genes may be repressed. 

AMOG adhesion molecule on glia CBP CREB-binding protein... 

ZnFZZ Zinc-binding domain, present in Dystrophin, CREB-binding protein E(MFP) 2(2) 11(12) ... 

Jin, Y., et al., MDM2 mediates p300/ CREB-binding protein-associated factor ubiquitination and degradation. 

Lu Q, Hutchins AE, Doyle CM, Lundblad JR, Kwok RP (2003) Acetylation of CAMP-responsive element-binding protein (CREB) by CREB-binding protein enhances (REB-dependent Transcription. J Biol Chem. 278(18) 15727-15734... 

Sakaguchi K, Herrera JE, Saito S, Mild T, Bustin M, Vassilev A, Anderson CW, Appella E (1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 12( 18) 2831-2841 Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (2000). Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. Mol Cell Biol 20(23) 8933-8943... 

Abbreviations CBP, CREB binding protein CREB, cAMP response element binding protein FAT, factor acetyltransferase HAT, histone acetyltransferase MEL, mixed lineage leukaemia protein MORE, MOZ related factor MOZ, monocytic leukaemia zinc finger protein PHD, plant homeodomain RTS, Rubinstein-Taybi syndrome, TIE, transcription intermediary factor... 

Kurokawa R, Kalafus D, OgUastro MH, Kioussi C, Xu L, Torchia J, Rosenfeld MG, Glass CK (1998) Differential use of CREB binding protein-coactivator complexes. Science 279 700-703 Kwok RP, Lundblad JR, Chrivia,JC, Richards JP, Bachinger HP, Brennan RG, Roberts SG, Green MR, Goodman RH (1994) Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370 223-226... 

Shigeno K, Yoshida H, Pan L, Luo JM, Fujisawa S, Naito K, Nakamura S, Shinjo K, Takeshita A, Ohno R, Ohnishi K (2004) Disease-related potential of mutations in transcriptional cofactors CREB-binding protein and p300 in leukemias. Cancer Lett. 213 11—20 Shiio Y, Eisenman RN (2003) Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci U S A 100 13225-13230... 

Vo N, Goodman RH (2001) CREB-binding protein and p300 in transcriptional regulation. J Biol Chem... 

An explanation for this net deacetylation throughout neurodegeneration is that neuronal cells progressively lose a HAT, and more particularly, the CREB binding protein (CBP) (reviewed below and in (Rouaux et al, 2004 Saha and Pahan 2006)... 

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