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Disease therapy, animal

Human genome map Identification of disease genes Animal cloning Human gene therapy IND J... [Pg.5]

Successful application of ocular gene therapy has been demonstrated in animal diseases or animal models of human disease. The most encouraging results in the field of ocular gene therapy involve treatment of genetically inherited retinal degenerations occurring in various animal species. Conventional pharmacologic approaches... [Pg.163]

Polyene antibiotics can be also used to enhance several-fold the efficiency of DNA-mediated gene transfer in mammalian cells (24), to inhibit the replication of HIV (25), or to delay the incubation period of a putative prion-caused disease of man (Creutifeldt-Jakob disease) and animals. At the moment, no therapy is available for the cure of these fata central nervous system diseases (26). [Pg.557]

In 1971, levamisole, an anthelmintic compound widely used in catde and swine, was shown to improve the effects of an experimental Brucella abortus vaccine in mice. Since that time, the veterinarians and physicians have explored the effects of levamisole in such diverse areas as arthritis, lupus erythematosis, cancer therapy, respiratory diseases, Newcastle disease, foot-and-mouth disease, mastitis, and vaccine potentiation. Although the exact mechanism of action has as yet not been deterrnined there is substantial evidence that, under defined circumstances, levamisole can augment the animal s natural immune response (9). New immunostimulants include Staph Ijysate acemannon, NLAB-31. [Pg.406]

Pentylenetetrazol (188) is a drug with profound stimulatory activity on the central nervous system. As such, the agent was at one time used in shock therapy for treatment of mental disease. Although it has since been supplanted by safer methods, the agents still occupy an important role in various experimental animal models in pharmacology. Addition of hydrazine to the imino ether (186) obtained from caprolactam affords 187. Treat-... [Pg.281]

In recent years increasing attention has been paid to the possibility of delaying or even reversing the memory loss that accompanies old age or the more tragic loss of human capabilities associated with premature senility - Alzheimer s disease. Progress is hampered by the difficulty of identifying suitable animal tests, and there is presently no reliable therapy. [Pg.127]


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See also in sourсe #XX -- [ Pg.413 , Pg.414 , Pg.415 ]




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Disease therapy

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