Cloning animal

Dolly the sheep, the first animal cloned from an adult cell, is born... 

Human genome map Identification of disease genes Animal cloning Human gene therapy IND J... 

While the success in animal cloning is a major achievement, it also raises ethical concerns about attempts to use parallel technology to clone humans. This strategy has been shown to be a viable one for mice, pigs, goats, and cattle. The donor nucleus can be engineered and faithfully and efficiently produced as animal clones that... 

BOX 15.1. BASIC CONCEPT OF NUCLEAR TRANSFER TECHNOLOGY IN ANIMAL CLONING... 

In animal cloning, researchers introduce foreign DNA primarily with the use of viral vectors or microinjection. These techniques can produce transgenic animals and provide new methods for human gene therapy. 

Where not q>ecificalfy stated, the affinity for the cloned subtypes in Tables 1 and 2 was determined in the animal clones. 

Ishida, 1., Tomizuka, K., Yoshida, H., Tahara, T, Takahashi, N., Ohguma, A., Tanaka, S., Umehashi, M., Maeda, H., Nozaki, C., Halk, E., Lonberg, N. Production of human monoclonal and polyclonal antibodies in TransChro-mo animals. Cloning Stem Cells 2002, 4, 91— 102. 

Robert P. Lanza, Jose B. Cibelli, Catherine Blackwell, Vincent J. Cristofalo, Mary Kay Francis, Gabriela M. Baerlocher, Jennifer Mak, Michael Schertzer, Elizabeth A. Chavez, Nancy Sawyer, Peter Lansdorp and Michael West, Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science, 288 (2000), 665-669. 

First somatic gene therapy to cure ADA-SCID First transgenic cow produces human proteins in milk 1994 Approval of DNAse for cystic fibrosis 1997 First animal cloned from adult cell (Dolly)... 

Animal clones are genetically identical to their predecessors (here is where the word parent really loses its meaning). Clones have been made for quite a few years by separating the cells of immature embryos and implanting each cell in the womb of a separate mother. All such animals are identical, making this process attractive for reproduction of livestock animals with special traits (such as the ability of dairy cows to produce a very large amount of milk or to produce exotic tnochonicals in their milk). 

So far, animal clones developed from somatic cells have shown several weaknesses that clones from separated embryonic cells have not shown. One of these is premature aging, possibly caused by the shortened telomeres on the ends of the DNA strands taken from the original somatic cells. There have been other physical weaknesses noted, as well. Thus, animal cloning is still in its infancy. 

Farmers and others have a keen interest in animal cloning. Imagine a dairy farmer had a cow that could naturally produce twice as much milk as other cows. If you could clone this cow, then the farmer would not need as... 

Dolly, the first animal cloned from embryonic stem cells Wilmut et al. (1997)... 

A few animal cloning industries market techniques for cloning pets. Genetic Savings and Clone is one such company. A related company, Viagen, which is part of Exeter Life Sciences, offers commercial cloning services for fiirm animals. 

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