Ethylenedi amine

There is also a bewildering variety of structural motifs in polytelluride-ligand complexes as the brief selection in Fig. 16.10 indicates the original papers should be consulted for preparative routes and other details. Thus, dissolution of the alloy K2Hg2Te3 in ethylenedi-amine, followed by treatment with a methano-lic solution of [NBu JBr, yields the dark brown... 

Optically active /3-ketoiminato cobalt(III) compounds based on chiral substituted ethylenedi-amine find use as efficient catalysts for the enatioselective hetero Diels Alder reaction of both aryl and alkyl aldehydes with l-methoxy-(3-(t-butyldimethylsilyl)oxy)-1,3-butadiene.1381 Cobalt(II) compounds of the same class of ligands promote enantioselective borohydride reduction of ketones, imines, and a,/3-unsaturated carboxylates.1382... 

There is apparently no analog of the reaction 2eh H2 in liquid ammonia, where eam is very stable. The loss of paramagnetism in concentrated solutions has been interpreted to be either by formation of (eam)2 or by association with metal cation in neither case is the spectral shift drastic. For Na in ethylenedi-amine (EDA), Dye et al. (1972) measured the rate of 2es— (es)2 as 1.7 x 109 M s-1, which is comparable to that of the corresponding reaction in water, 6 x 109 M-1s, although the products are different. A few rate constants have been measured in cesium-EDA systems, but it is not clear whether the electron or an associated form of the electron and the cation is the reactant. 

Kim and Varma have described the preparation of a range of cyclic ureas from diamines and urea [366]. In the example highlighted in Scheme 6.203, ethylenedi-amine and urea were condensed in the presence of 7.3 mol% of zinc(II) oxide in N,N-dimethylformamide as solvent at 120 °C to furnish imidazolidin-2-one in 95% isolated yield. Key to the success of this method is that the reaction needs to be performed under reduced pressure in order to remove the ammonia formed from the reaction mixture. This method was extended to a variety of diamines and amino alcohols [366]. 

It has also been found that alkali metals dissolve in solvents such as methylamine and ethylenedi-amine. These solutions have some characteristics of the solutions containing ammonia, and they... 

Gold(III)/silver(I) Luminol-K2 S 208-ethylenedi amine 0.05-5/0.1-10 / A YHF-1 liquid CL analyzer was used 65... 

A mixture of (triisopropyl phosphito)copper(I) bromide (17.6 g, 0.05 mol) and l-bromo-2,2-diphenylethylene (9.1 g, 0.035 mol) was heated at 200°C for 1 h under a nitrogen atmosphere in a flask equipped with a Vigreaux column topped by a Dean-Stark trap. The alkyl halide produced in the reaction was collected in the trap. After cooling, the reaction mixture was poured into toluene (60 ml), and ethylenedi-amine was added (5 ml). After filtering and washing the precipitate with toluene, the combined toluene solutions were washed with 10% hydrochloric acid (10 ml) and water (10 ml), dried over magnesium... 

Two of these systems were studied as models—the acetylation of choline in brain to give acetyl choline (Hebb, Nachmansohn), and of sulfanilamide (the active component in prontosil, Chapter 3) in liver (Lipmann). Sulfanilamide is rapidly inactivated by acetylation on the p-amino group and then excreted. Sulfanilamide is easily diazotized the diazonium salt formed can be coupled with N-( 1 -naphthyl)ethylenedi-amine dihydrochloride to give a pink derivative (Bratton and Marshall, 1939). This formed the basis for an elegant colorimetric assay. Only the free p-amino group reacts, so that as acetylation proceeded color formation diminished. 

In a second step, the gel is fimctionahzed for NA attachment. Common methods for polyacrylamide gel fimctionahzation are based on the treatment of the polymerized support with reagents such as hydrazine or ethylenedi-amine. These treatments generate amine groups in the gel that can react with amine-modified ONDs via glutaraldehyde coupling, or directly with oxidized DNA probes (Fig. 15). Alternatively, the fimctional groups may be introduced by copolymerization reactions (e.g. co-polymerization with N-hydroxysuccinimide acryhc or oxirane acryhc derivatives) [59]. 

The unsubstituted salt (6,R=R =H) is obtained in this way only in low yield. A much better method is available in the reaction of a salt of the bisanil, or better the bis(A-phenylanil) of malonaldehyde with ethylenedi-amine (73S791). 

Powell, D. B., Scott, J. G. Infrared spectra of the thiophosphates of tris(ethylenedi-amine)cobalt(IIl). Spectrochim. Acta28A, 1067 (1972). 

Twenty years ago theophylline (Theo-Dur, Slo-bid, Uniphyl, Theo-24) and its more soluble ethylenedi-amine salt, aminophylline, were the bronchodilators of choice in the United States. Although the p2-adreno-ceptor agonists now fill this primary role, theophylline continues to have an important place in the therapy of asthma because it appears to have antiinflammatory as well as bronchodilator activity. 

The polarographic experimental and calculated curves of complex formation with the following ligands N, Ai -bis(2-pyridyl methyl)- ,2-diaminoethane [118], picolinic acid [119], Ai-(2-hydroxyethyl)ethylenedi-amine [120], 1-hydroxyethylenediphospho-nic acid [121], and Ai-(2-hydroxyethyl)imi-nodiacetic acid [122] was used for modeling the Cd(II)-Kgand systems. The stoichiometry and stability constants of formed complexes were evaluated. The same method was used for determinations of stability constants of Cd(II) complexes with monoaza-12-crown-4 ether in aqueous solution in the presence of an excess of sodium ions [123]. 

Fig. 1.1.17 Composition domains of well-defined particles formed by aging at 90"C for 1 h solutions containing zinc nitrate and different bases. TEA triethanolamine En ethylenedi-amine. (From Ref. 110.)...

A triethanolamine/ammonia bath has been used for CdSe [19]. While this system resulted in thick films for CdS (up to a few microns), CdSe films deposited under the same conditions, only using selenosulphate instead of thiomea, were thinner [although films of 500 nm were obtained at 30°C that did not show signs of satuation (of thickness) after 25 hr—the longest time measmed]. Ethylenedi-amine has also been used as a complex for Cd, with both precipitates and films formed [86]. In this case, the emphasis was on the precipitates, and no characterization was carried out on the films. 

Piperazines, in contrast to pyrazines, abound in medicinal agents that moiety quite often occurs in side chains serving as a surrogate tertiary amine or as an ethylenedi-amine. A number of these have aheady been covered in passing in earlier chapters. The examples that follow have been chosen to illustrate the varied synthetic strategies... 

N,N -Dimethyl-N,N -d initroso-ethylenedi-amine or 2,5-Dinitroso-2,5-diazahexane,... 

These complexes are rare, doubtless owing to the comparatively ready oxidation of amines. However, the template preparation of Ce(N03)4L-3H20 has been described L is the eighteen-membered macrocycle formed by cocondensation of two molecules of ethylenedi-amine and two molecules of 2,6-diacetylpyridine. The structure of this compound is unknown and it is uncertain to what extent the macrocycle is bonded to the metal ion.689... 

Since platinum(IV) complexes are also kinetically inert, optical diastereomers of Pt(en)2(L-2,3-diaminopropionic acid)4+ have been prepared.1028 The first synthetic procedure involves the chlorine oxidation of PtCl2(L-2,3-diaminopropionic acid) followed by reaction with ethylenedi-amine. Resolution is achieved through the (+)-tartrate salt. Alternatively the resolved complex can be prepared directly from the reaction of L-2,3-diaminopropionic acid on optically active cis-[PtCl2(en)2]Cl2. (... 

The chlorides of the other polyhasic ammine complexes with cobalt described in (II) may easily be prepared in solution by a similar procedure, but only the ethylenedi-amine compound can be directly isolated as a solid. The other chlorides must be made indirectly from the nitrates, bromides, or iodides of the respective series,... 

Twenty grams of neutral traws-dichlorobis (ethylenedi-amine)cobalt (III) chloride (No. 131) are suspended in 30ml of water and 6.8g of potassium thiocyanate is added to the green solution. A green precipitate of the thiocyanate immediately forms. The mixture is warmed on the steam bath the suspension turns grey, and finally all the solid dissolves to yield a bluish-red solution. After the vessel is cooled in ice and the walls are scratched, the cis-product crystallizes out it is filtered off and then washed with 15ml of ice-cold water. 

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