Dermal fillers

Collagen dermal filler CosmoDerm (Adv. Tissue Sci./Inamed) Wrinkles... 

Trade name Radiesse (BioForm) (Radiance FM) Indications Correction of facial wrinkles and folds Category Dermal filler Half-life N/A... 

If the patients in Figures 5.13(a) and 5.14(a) want quick rejuvenation that will last around 15 years, a phenol peel is the only indication (Figures 5.13(b) and 5.14(b)). The extent of the problems would be beyond dermal fillers, and if these were used, the results would be temporary. 

Filling techniques can also be used immediately before ETCA, as the ETCA post-peel cream soon stops inflammation and oxidation. The cream can also absorb the free radicals that are released by the peel and that could damage the three-dimensional structure of dermal fillers, such as hyaluronic acid. In fact, the instructions for most dermal filler products specify not to apply a peel after the filler, but... 

Folds, wrinkles and fine lines should be treated beforehand with dermal fillers, thread lifts, mesotherapy, stimulation or any other treatment chosen by the doctor. Benign tumors can be excised or treated by shave biopsy or lasers. Rosacea should be treated before the peel during this same period. Botulinum toxin, ideally should be injected 8 days before the first water-based glycolic acid peel. 

Folds cannot be treated by peels, and require surgery, dermal fillers or thread lifts. Deep nasolabial folds and marionette lines do not always respond to phenol. 

Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, Voorhees JJ. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol 2007 143 155-163. 

Recently, cross-linked gels of HA have transformed the esthetics and dermatology areas. These HA-based products are remarkably safe and serve as tissue-bulking agents to correct wrinkles and other skin defects. Restylane (27-29), Hylaform (30-33), Captique (34), and Juvederm M (35) are a few representative examples of HA-based dermal fillers that have been approved for skin depression in nasolabial folds. 

Pollack S. Some new injectable dermal filler materials hylaform, restylane, and artecoll. J Cutan Med Surg 1999 3(Suppl. 4) S27-S35. 

S.S. Johl, R.A. Burgett, Dermal filler agents a practical review, Cuir. Opin. Ophthalmol. 17 (2006) 471-479. 

N.J. Lowe, C.A. Maxwell, R. Patnaik, Adverse reactions to dermal fillers review, Dermatol. Surg. 31 (2005) 1616-1625. 

Dastoor, S. F., Misch, C. E. Wang, H. L. (2007) Dermal fillers for facial soft tissue augmentation. J Oral Implantol, 33, 191-204. 

Presscott AG. Dermal filler and method cf using same 2013. Patent US 8486467 B1. 

K. Cockerham, and V. Hsu, Collagen-based dermal fillers Past, present, future. Facial Plast. Surg, 25 (02), 106-113,2009. 

Kablik, J., Monheit, G.D., LiPing, Y., et al. (2009) Comparative physical properties of hyaluronic acid dermal fillers. Dermatologic Surgery, 35, 302-312. 

Dermal filler Recover soft-tissue volume of the skin and remove skin wrinkles... 

If soft tissue fillers are used for deeper rhytids or facial volume replacement the procedures should be performed two weeks to one month prior to peehng or resurfacing. The deeper fillers in subcutaneous tissue and below are too deep to be affected by peel or laser, but superficial dermal fillers should be performed after resurfacing. 

Pollack SV 1999 Some new injectable dermal filler materials ... 

Over the past two decades, HA has become the most extensively used material in plastic surgery, ophthalmology and orthopaedics. The use of HA in reconstructive surgery, as a dermal filler, dressing, or cream, centres on the restoration of soft tissue defects, and the treatment of wounds and burns. Typically, these defects are secondary to surgical or physical trauma, especially in subtractive surgeries, such as tumour removal. HA is used as a filler due to its ability not only to restore the lost volume, but to also improve the quality of the skin, namely its elasticity, plasticity and hydration. 

There are other absorbable fillers, such as collagen (bovine- or porcine-derived) injections, calcium hydroxyapatite (biodegradeable microparticles), poly(L-lactic acid) (PLLA) and non-absorbable fillers such as Artefill (polymethyl methacrylate (PMMA) with collagen) and silicone injections. Table 7.1 lists the most popular dermal fillers available in the United States [18]. Compared to the above-mentioned fillers, HA has the safest biological profile, and it is fully absorbable and biodegradable [19]. Crosslinking of its macromolecular chains increases its resistance to degradation by matrix metalloproteinases and extends its life in the body [6]. 

Table 7.1 Most popular dermal fillers available in the USA... 

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