Collagen products

Moy LS, Howe K, Moy RL (1996) Glycolic acid modulation of collagen production in human skin fibroblast cultures in vitro. Dermatol Surg 22(5) 439-441... 

Inhibitors for 2-OG dependent iron oxygenases thus have a huge pharmaceutical potential as future drugs. In particular inhibitors for prolyl 4-hydroxylase could help to control collagen production (34,36). Such an inhibitor should mimic the k 0, 0 chelate coordination of 2-OGs but should not react with O2. A -Oxalylglycine (Fig. 3) is such an inhibitor for prolyl 4-hydroxylase (IC50 = 3 pM) (34,36). 

Structural — collagen production for vessel walls, skin, bones, and teeth ... 

Vitamin C deficiency leads to impaired collagen production and defective collagen structure,... 

Granstein RD, Flotte TJ, Amento EP. Interferons and collagen production. Journal of Investigative Dermatology 1990, 95, 75S-80S. 

I. Ogata, S. Mochida, T. Tomiya, and K. Fujiwara, Minor contribution of hepato-cytes to collagen production in normal and early fibrotic Rat Livers, Hepatology 74 361-367 (1991). 

Butt, R.P., Laurent, G.J., and Bishop, J.E. 1995. Collagen production and replication by cardiac fibroblasts is enhanced in response to diverse classes of growth factors. Eur. J. Cell Biol. 68 330-335. 

Figure 27.18. Example of cytokine-growth factor cascades that contribute to myofibroblast proliferation and collagen production during fibrogenesis.

It is known that the first aldehyde metabolite of alcohol, acetaldehyde, stimulates collagen transcription in vitro in hepatic fibroblasts and lipocytes [85,86], suggesting a link with alcoholic liver fibrosis in vivo. Chojkier et al. [84] have shown that the lipid-peroxidation product malondialdehyde also increases collagen production 2-3-fold in cultured foetal fibroblasts. The way in which... 

Aberrant Collagen Production (TVpes VI, VIII) Wound Contraction... 

Biological products were developed traditionally, before recombinant proteins, as extracts or derivatives of the actual protein from the human body or nature. This approach continues today and Table 15 lists 18 such products, mostly blood derivatives for therapeutic use. Albumin is obtained for cardiovascular volume conditions. A fish protein is harvested for osteoporosis. Igs extracted from blood are available for immunodeficiency conditions, viral infections (hepatitis-B and vaccinia), hemolytic anemia in newborns, and idiopathic thrombocytopenic purpurea. Antihemophilic products are still derived from blood. An antiglobulin is produced for kidney transplant rejection. A collagen product and two botulinum toxin products are used for various facial wrinkle problems and cervical dystonia. A bacterial antigen is formulated to enhance immunity to treat a cancer. 

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