Depressants, of central nervous system

Health Hazards Information - Recommended Personal Protective Equipment Protective goggles, gloves Symptoms Following Exposure Irritation of mucous membranes and stimulation followed by depression of central nervous system. Breathing of vapor may also cause dizziness, headache, and in... 

Symptoms of exposure Exposure to high concentrations may produce depression of central nervous system. Symptoms include excitement, loss of equilibrium, stupor, and coma (Patnaik, 1992). 

Symptoms of exposure Lacrimation, depression of central nervous system, anesthesia, and liver damage (Patnaik, 1992). An irritation concentration of 150.00 mg/m in air was reported by Ruth (1986). 

Symptoms of exposure Depression of central nervous system, irritation of eyes, corneal opacity, nausea, vomiting, diarrhea, ulceration, somnolence, cyanosis, pulmonary edema, coma. Ingestion of liquid may cause death (Patnaik, 1992). 

Symptoms of exposure May cause weakness, confusion, depression of central nervous system. 

Symptoms of exposure May cause depression of central nervous system and irritation of eyes, skin, and respiratory tract (Patnaik, 1992)... 

Most anxiolytic and sedative-hypnotic drugs produce dose-dependent depression of central nervous system function. The ideal anxiolytic drug should calm the patient without causing too much daytime sedation and drowsiness and without producing physical or psycho-... 

CNS Barbiturates produce depression of central nervous system in dose dependent manner. In small dose, barbiturates relieve anxiety and are generally used as sedative. In hypnotic dose, it produces sleep resembling normal physiological sleep. Hypnotic dose of barbiturates produce motor incoordination. 

Disadvantages of the benzodiazepines include the risk of dependence, depression of central nervous system functions, and amnestic effects. In addition, the benzodiazepines exert additive central nervous system depression when administered with other drugs, including ethanol. The patient should be warned of this possibility to avoid impairment of performance of any task requiring mental alertness and motor coordination. In the treatment of generalized anxiety disorders and certain phobias, newer antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), are now considered by many authorities to be drugs of first choice (see Chapter 30). 

SAFETY PROFILE Moderately toxic by inhalation and ingestion. A skin and human eye irritant. Human systemic effects by inhalation nausea or vomiting, conjunctiva irritation, unspecified effects on the sense of taste. Inhalation of vapors causes irritation of lungs and depression of central nervous system. Prolonged exposure may result in damage to liver and kidneys. Flammable when exposed to heat or flame. 

General anaesthesia is obtained by means of a variety of structurally unrelated compounds that are able to induce a global but reversible depression of central nervous system function, resulting in the loss of response to and perception of external stimuli. 

Tetrafluoro-ethylene (TFE) (CF2=F2) Causes acute effects when inhaled, including irritation of upper respiratory tract and eyes, mild depression of central nervous system, nausea and vomiting, and dry cough. Massive inhalation produces cardiac arrhythmia, cardiac arrest, and death. A study by National Toxicology Program has reported kidney and liver tumors in rats and mice, which had exposed to hfetime inhalation of TFE. Relationship to human response has not been established. An exposure limit of 5ppm has been established by fluoropolymer producers. 

These agents act at the level of the brain stem to initiate muscle relaxation. This may be related to a blockade of afferent pathways, or by a central depression of central nervous system (CNS) function. 

HUMAN HEALTH RISKS Acute Risks irritation of eyes, mucous membranes and upper respiratory tract severe skin burns depression of central nervous system weeping and twitching of eyelids headaches Chronic Risks disturbances of liver functions may cause cancer may cause genetic damage pulmonary edema more susceptible to illness. 

HEALTH SYMPTOMS Inhalation (headache, nausea, vomiting, mild depression of central nervous system, lung irritation, unconsciousness) contact (severe irritation of skin and eyes). 

ACUTE HEALTH RISKS irritation to eyes, skin, and upper respiratory tract depression of central nervous system headache dizziness drowsiness lassitude weariness excitation shortness of breath sore throat abdominal pain nausea vomiting chemical pneumonitis convulsions exposure to very high levels can result in loss of consciousness and death. 

ACUTE HEALTH RISKS irritation of eyes and skin irritation of nose and throat, causing coughing and wheezing can cause headache, lightheadedness, dizziness, incoordination and fainting depression of central nervous system irritation of surface tissues paralysis of respiratory center acute pulmonary edema high concentrations may cause unconsciousness and death. 

ACUTE HEALTH RISKS irritation of eyes, nose, throat, and skin narcosis-depression of central nervous system sleepiness loss of consciousness. 

ACUTE HEALTH RISKS severe irritation of eyes and skin severe respiratory irritation corrosive to the mucous membranes and lungs irritating to the nose and throat allergic reaction may occur depression of central nervous system. 

ACUTE HEALTH RISKS irritation to eyes skin, and respiratory system redness of face dilation of pupils rapid pulse cyanosis respiratory disorder respiratory paralysis collapse pulmonary edema slight headache vertigo dizziness slurred speech anesthesia cardiac arrest depression of central nervous system conjunctival hyperemia hemorrhages in conjunctiva loss of consciousness death. 

ACUTE HEALTH RISKS throbbing headache dizziness flushing palpitations delirium hypotension (lowered blood pressure) weakness abdominal pain nausea vomiting depression of central nervous system methemoglobinemia angina may cause skin irritation may result in death. 

HEALTH SYMPTOMS inhalation (narcosis, anesthesia, irritates eyes, nose and throat) contact (irritates eyes and skin) ingestion (depression of central nervous system, injury to kidneys and liver). 

ACUTE HEALTH RISKS mild irritation of eyes, nose and throat drowsiness headache ataxia (nosebleed) depression of central nervous system gastrointestinal pain abdominal cramps nausea vomiting diarrhea death from respiratory failure. 

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