Dengue

Biology and Control ofMedes aegypti, Hector Topics No. 4 and Dengue Surveillance Survey No. 9, U.S. PubHc Health Service, Centers for Disease Control and Prevention, Adanta, Ga., 1979 and 1983. 

A large and rapidly growing number of clinical trials (phase I and phase II) evaluating the potential of DNA vaccines to treat and prevent a variety of human diseases are currently being performed ( http // clinicaltrials.gov) however, there is yet no licensed DNA vaccine product available for use in humans. The clinical trials include the treatment of various types of cancers (e.g., melanoma, breast, renal, lymphoma, prostate, and pancreas) and also the prevention and therapy of infectious diseases (e.g., HIV/ABDS, malaria, Hepatitis B vims, Influenza vims, and Dengue vims). So far, no principally adverse effects have been reported from these trials. The main challenge for the development of DNA vaccines for use in humans is to improve the rather weak potency. DNA vaccines are already commercially available for veterinary medicine for prevention of West Nile Vims infections in horses and Infectious Hematopoetic Necrosis Vims in Salmon. 

Melino S, Paci M (2007) Progress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach. FEES J 274 2986-3002 Murphy RL, Brun S, Hicks C, Eron JJ, GuUck R, King M, White AC Jr, Benson C, Thompson M, Kessler HA, Hammer S, Bertz R, Hsu A, Japour A, Sun E (2001) ABT-378/ritonavir plus stavudine and lamivudine for the treatment of antiretroviral-naive adults with HIV-1 infection 48-week results. AIDS 15 E1-E9... 

Qin CF, Qin ED (2006) Capsid-targeted viral inactivation can destroy dengue 2 virus from within in vitro. Arch Virol 151 379-385... 

Viral vaccines less generally available than those listed in die table include Congo Crimean haemorrhagic fever vaccine, dengue fever vaccine, Japanese encephalitis B vaccine, smallpox vaccine, tick borne encephalitis vaccine, and Venezuelan encephalitis vaccine. 

Diseases which will probably be subject to control by insecticides but have not yet been adequately tested include sandfly fever, dengue, urban yellow fever, bartonellosis, cutaneous leishmaniasis, Chagas disease, filariasis, trench fever, and louse-born relapsing fever. Some of the virus encephalitides. sleeping sickness, and visceral leishmaniasis may also be susceptible of control. 

A winter outbreak of typhus had been stopped for the first time in history. DDT also halted a flea-borne plague epidemic in West Africa a dengue fever epidemic on Saipan in the West Pacific and a typhus epidemic during the U.S. occupation of Japan in late 1945. When the Allies liberated German concentration and labor camps, their lice-laden inmates were dusted with DDT before they were evacuated. Typhus had been a major cause of death in the camps. The commander of Auschwitz, where three million... 

Ebola-gp 1, or Dengue-gp E. DC-SIGN is also known to oligomerize, and it is therefore particularly important to understand the intrinsic binding and multivalent binding requirements of this lectin. 

Suggested Alternatives for Differential Diagnosis Adenoviruses, arenaviruses, California encephalitis, coxsackieviruses, cytomegalovirus, dengue fever, eastern equine encephalitis, echoviruses, infectious mononucleosis, Japanese encephalitis, Lyme disease, meningitis, parainfluenza virus, rhinoviruses, bacterial sepsis, severe acute respiratory syndrome (SARS), St Louis encephalitis, upper respiratory infection, Venezuelan encephalitis, and West Nile encephalitis. 

Suggested Alternatives for Differential Diagnosis Dengue, measles, Rocky Mountain spotted fever, rubella, tick bite fever, epidemic typhus, Q fever, typhoid, malaria, trypanosomiasis, hepatitis, infectious mononucleosis, herpes, and influenza. 

Mortality Rate (untreated) "Rare" (classic dengue) <40% (hemorrhagic). 

Suggested Alternatives for Differential Diagnosis Other forms of encephalitis (e.g., California, Eastern Equine, St Louis, West Nile, Murray Valley), malaria, dengue fever, meningitis, tuberculosis, typhoid fever, enteroviruses, herpes simplex, and Nipah virus. 

Suggested Alternatives for Differential Diagnosis Acanthamoeba, louse-borne relapsing fever, dengue fever, Rift Valley fever, hemorrhagic fevers, leptospirosis, malaria, typhoid fever, typhus, liver failure, and hepatitis. 

Material Safety Data Sheet-Infectious Substances Dengue Fever Virus (DEN 1, DEN 2, DEN 3,... 

Fact Sheet 117 Dengue and Dengue Hemorrhagic Fever. Geneva Health Communications and... 

Suggested Alternatives for Differential Diagnosis Anthrax, brucellosis, dengue, ehrlichiosis, infectious mononucleosis, Kawasaki disease, leptospirosis, malaria, meningitis, men-ingococcemia, relapsing fever, Rocky Mountain spotted fever, syphilis, toxic shock syndrome, toxoplasmosis, tularemia, typhoid fever, rubella, measles. 

Kumarasamy, V. Wahab, A. H. A. Chua, S. K. Hassan, Z. Chem, Y. K Mohamad, M. Chua, K. B., Evaluation of a commercial dengue NS1 antigen capture ELISA for laboratory diagnosis of acute dengue virus infection, J. Virolog. Methods 2007, 140, 75 79... 

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