Dendritic cells immunity

Van Vliet SJ. den Dunnen J. Gringhuis SI. Geijten-beek TB. van Kooyk Y Innate signaling and regulation of dendritic cell immunity. Curr Opin Immunol 2007 19 435-440. 

Wang YH, Ito T, Wang YH, Homey B, Watanabe N, Martin R, Barnes CJ, McIntyre BW, Gilliet M, Kumar R, Yao Z, Liu YJ Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 2006 24 827-838. 

Svensson M, Maroof A, Ato M, Kaye PM Stromal cells direct local differentiation of regulatory dendritic cells. Immunity 2004 21 805-816. 

Parallel to orchestrating acute inflammatory processes by providing an optimal milieu of cytokines, mediators, and adhesion molecules in order to recruit and activate effector cells to the site of infection, dendritic cells also setve as professional antigen-presenting cells for cells of the adaptive immune system ( antigen presentation ... 

In the specialized environment of secondary lymphoid tissues such as lymph nodes or spleen, dendritic cells provide the requirements for naive T-lymphocytes to become activated and to proliferate. The professional antigen-presenting cells present peptides in MHC II, express costimulatory molecules, and release cytokines into the immunological synapse, which is formed by the antigen-presenting cell and the naive T-lymphocyte. Thus, cells of innate immunity initiate and facilitate the activation of naive lymphocytes, and it is easily conceivable that their cytokines and adhesion molecules will instruct the naive T-lymphocyte during activation and differentiation to T-effector cells. 

NF-kB regulates both innate and adaptive immune responses ( immune defense) [2]. Understanding the function of NF-kB in the development, maintenance, and activation of cells from the immune system (including hematopoietic cells, macrophages, dendritic cells, B and T lymphocytes) has greatly benefited from the analysis of knockout mice in which individual NF-kB family members were defective. 

Janeway CA Jr, Medzhitov R Innate immune recognition. Armu Rev Immunol 2002 20 197-216. Kapsenberg ML Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 2003 3 984-993. 

Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin- 10-treated dendritic cells and transforming growth factor-p for their induction. Clin Exp Allergy 2006 36 1546-1555. 

Vicari AP, Figueroa DJ, Hedrick JA, et al. TECK a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 1997 7 291-301. 

Regulation by Chemokines of Dendritic Cell Migration-Dependent Immunity... 

Allan RS, Smith CM, Belz GT, et al. Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science 2003 301(5641) 1925—1928. 

Cook DN, Prosser DM, Forster R, et al. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 2000 12(5) 495-503. 

Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392 245-252... 

Uto T, Wang X, Sato K et al (2007) Targeting of antigen to dendritic cells with poly ( /-glutamic acid) nanoparticles induce antigen-specific humoral and cellular immunity. J Immunol 178 2979-2986... 

Stagg AJ, Hart AL, Knight SC, Kamm MA Microbial-gut interactions in health and disease. Interactions between dendritic cells and bacteria in the regulation of intestinal immunity. Best Pract Res Clin Gastroenterol 2004 18 255-270. 

Inflammation and autoimmunity often are associated with the destruction of bone, but the molecular link between these two processes had long been unclear. The role of bone in the generation of immune system cells is evident since they are formed in the marrow housed within the bone however, the role of these cells on bone is not so clear. RANKL and RANK were described initially in activated T-cells and in dendritic cells, respectively, where they have functions in the regulation of cellular lifespan and immunomodulation (Anderson et al. 1997 Wong et al. 1997). Recently the term osteoimmunology has been coined to describe the link between the immune system and bone (Arron et a. 2000). Several data support this idea ... 

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