Drug design delivery

In conclusion, until now insufficent data have been available to define general rules to predict for which drugs liposome encapsulation will be therapeutically beneficial when applied to the skin. It is too early to draw definite conclusions about the advantage of the vise of liposomes over alternative dermal delivery systems in the therapy for drugs designed to exert a pharmacological effect either locally or systemically. 

R. P. New approaches to drug design and delivery based on drug-membrane interactions. Drug Des. Deliv. 1991, 7, 75-118. 

Feazell, R.P. et al. (2007) Soluble single-walled carbon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design. Journal of the American Chemical Society, 129 (27), 8438-8439. 

Kompella, U.B. and Lee, V.H.L. 2001. Delivery systems for penetration enhancement of peptide and protein drugs design considerations. Advanced Drug Delivery Reviews 46, 211-245. 

G. M. Barratt, C. Morin, M. Appel, and I. Seyler, Intracellular delivery of a muramyl dipeptide derivative by poly(DL-lactide) nanocapsules, in In vitro and ex vivo test systems to rationalize drug design and delivery, Paris, 1993, pp. 265-268. 

R. H. Hammer, K. Amin, Z. E. Gunes, G. Brouillette, N. Bodor, Novel Soft Anticholinergic Agents , Drug Design Delivery 1988, 2, 207-219. 

H. van de Waterbeemd, B. Testa, C. Marrel, D. R. Cooper, P. Jenner, C. D. Marsden, Multivariate Statistical Analysis of L-Dopa Esters as Potential Anti-Parkinsonian Prodrugs , Drug Design Delivery 1987, 2, 135-143. 

A. El-Koussi, N. Bodor, Improved Delivery through Biological Membranes. XXV. Enhanced and Sustained Delivery of Trifluorothymidine to the Brain Using a Dihydropyridine <-> Pyridinium Salt Type Redox Delivery System , Drug Design Delivery 1987,... 

The drug in this case, a siRNA, was coupled to the RVG peptide and successfully delivered to the neurons in mice. This work opens up the possibility of using the RVG as delivery tools for drugs designed for interaction with brain neurons. 

Department of Chemistry, Center for Molecular Diversity in Drug Design, Discovery and Delivery, University of South Florida, Tampa, FL 33620, USA e-mail bjbaker usf.edu... 

Barbizhayev, M. A. (2008). Ocular drug metabolism of the bioactivating antioxidant N-acetylcamosine for vision in ophthalmic prodrug and codrug design and delivery. Drug Dev. Ind. Pharm. 34,1071-1089. 

Morishita, I., Morishita, M., Takayama, K., Machida, Y., and Nagai, T. (1991). Controlled release microspheres based on Eudragit L100 for the oral administration of erythromycin. Drug Design Delivery, 7, 309-319. 

FACTORS INFLUENCING ORAL MODIFIED-RELEASE DELIVERY SYSTEM DESIGN AND PERFORMANCE FOR WATER-INSOLUBLE DRUGS... 

Wiechers, J.W., and R.A. de Zeeuw. 1990. Transdermal drug delivery Efficacy and potential applications of the penetration enhancer azone. Drug Design Del 6 87. 

Vaginal rings are circular, torus-shaped, drug delivery devices designed to prolong drug release after application. They measure approximately 5.5 cm in diameter with a circular cross section of 4—9 mm [6,12]. 

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