Oral Mucosa and Design of Buccal Drug-Delivery Systems

1 Oral Mucosa and Design of Buccal Drug-Delivery Systems 

However, the action of saliva and the continuous swallowing thereof tends to wash away drugs applied to the mucosa, resulting in short retention time and low therapeutic efficacy. Therefore, proper design of a dosage form for use in the oral cavity is necessary [23], and to overcome some of these shortcomings, a buccal adhesive system of drug delivery has been developed and is under continued research for improvement [26,24,25]. 

---