Drug delivery prodrug design

W. Wang, J. Jiang, C. E. Ballard, B. Wang, Prodrug Approaches to the Improved Delivery of Peptide Drugs , Curr. Pharm. Design 1999, 5, 265 - 287. 

N. M. Nielsen, H. Bundgaard, Prodrugs as Drug Delivery Systems. 68. Chemical and Plasma-Catalyzed Hydrolysis of Various Esters of Benzoic Acid A Reference System for Designing Prodrug Esters of Carboxylic Acid Agents , Int. J. Pharm. 1987, 39, 75-85. 

Z. Shao, A. J. Hoffman, A. K. Mitra, Biodegradation Characteristics of Acyclovir 2 -Esters by Respiratory Carboxylesterases Implications in Prodrug Design for Intranasal and Pulmonary Drug Delivery , Int. J. Pharm. 1994, 112, 181 -190. 

H. Bundgaard, A. Buur, Prodrugs as Drug Delivery Systems. 65. Hydrolysis of a-Hy-droxy- and a-Hydroxy-V-benzoylglycine Derivatives and Implications for the Design of Prodrugs of NH-Acidic Compounds , hit. J. Pharm. 1987, 37, 185-194. 

Greenwald, R. B. Gilbert, C. W. Rendri, A. Conover, C. D. Xia, J. Martinez, A. Drug delivery systems water soluble taxol 2 -poly(ethylene glycol) ester prodrugs—design and in vivo effectiveness. J. Med. Chem., 1996, 39 424 31. 

The future design and use of prodrugs hold much promise in ocular drug delivery, particularly where lipophilic prodrugs can be induced to penetrate the blood-vitreous barrier readily and then are metabolized to a form that is trapped in the vitreous compartment. Because of their selective permeability, drugs could reach an effective concentration in the eye by entrapment... 

Wang, W., Jiang, J., Ballard, C.E. and Wang, B. (1999) Prodrug approaches in the improved delivery of peptide drugs. Current Pharmaceutical Design, 5,... 

Han HK, Amidon GL. Targeted prodrug design to optimize drug delivery. AAPS PharmSci 2000 2 1-11. 

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