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Degradation products availability

Whatever the sample matrix, ensure that blank matrices are available for recovery and selectivity studies. For impurity determinations, it is best to have impurity standards and degradation products available for selectivity studies and quantitative validation. For quantitative analysis of individual major components or impurities, internal standards are usually necessary to ensure precise quantitation. [Pg.16]

Are enriched samples with the unknown impurity/degradation products available ... [Pg.23]

In general, stabilizers function by reaction with proplnt decompn products. A number of methods have been described and a preliminary evaluation of these methods was conducted by several labs under a cooperative program. Based on results from these screening tests, the PicArsn spec tropho tome trie methods for available stabilizer and primary degradation products were selected for further study. The initial phase of this program was an attempt to standardize the necessary spectrophotometric factors. Significant differences with regard to the factors obtained... [Pg.944]

In 1947, L-rhamnose was first recognized by Stacey as a constituent of Pneumococcus Type II specific polysaccharide. This finding was confirmed, in 1952, by Kabat et al. and in 1955 again by Stacey when 2,4- and 2,5-di-O-methyl-L-rhamnose were synthesized and the former was shown to be identical with a di-O-methylrhamnose, obtained by hydrolysis of the methylated polysaccharide. This result indicated a pyranose ring structure for the rhamnose units in the polysaccharide. Announcement of the identification of D-arabinofuranose as a constituent of a polysaccharide from M. tuberculosis aroused considerable interest. The L-enantiomer had been found extensively in polysaccharides, but reports of the natural occurrence of D-arabinose had been comparatively rare. To have available reference compounds for comparison with degradation products of polysaccharides, syntheses of derivatives (particularly methyl ethers) of both d- and L-arabinose were reported in 1947. [Pg.13]

A number of laboratory tests are available to measure the phases of hemostasis described above. The tests include platelet count, bleeding time, activated partial thromboplastin time (aPTT or PTT), prothrombin time (PT), thrombin time (TT), concentration of fibrinogen, fibrin clot stabifity, and measurement of fibrin degradation products. The platelet count quantitates the number of platelets, and the bleeding time is an overall test of platelet function. aPTT is a measure of the intrinsic pathway and PT of the extrinsic pathway. PT is used to measure the effectiveness of oral anticoagulants such as warfarin, and aPTT is used to monitor heparin therapy. The reader is referred to a textbook of hematology for a discussion of these tests. [Pg.608]

Methods for Determining Parent Compounds and Degradation Products in Environmental Media. Analytical methods with the required sensitivity and accuracy are available for quantification of americium, both total and isotopic, in environmental matrices (see Table 7-2). Knowledge of the levels of americium in various environmental media, along with the appropriate modeling (see Chapters 3 and 5), can be used to evaluate potential human exposures through inhalation and ingestion pathways. [Pg.216]

If no references for the degradation products or impurities are available in the laboratory, the sample should be exposed to stress conditions such as heat (50-80 °C), ultraviolet light (2000 lux), acid and base (0.1-1 M HC1 and NaOH), and oxidant (3% H2O2). After incubation in the allotted time, the purity and identity of the analyte peak/spot should be proved by using DAD or MS detection (for LC), MS (for GC), or in situ UV-Vis measurement using a densitometry or TLC-MALDI MS (for TLC). [Pg.248]

In Phase III, the final dosage formulation has been established and the pivotal clinical trials are being conducted. Degradation products have been identified, so the method selectivity should be reevaluated to ensure that all degradants can be detected and quantitated. The analytical methods are completely validated, and appropriate for routine quality assurance and control purposes. The type and frequency of system suitable testing (SST) should be determined, and an excellent publication on SST for chromatography systems is available [47],... [Pg.257]

Specific information on physical appearance is not available for this material. This material is a degradation product from hydrolysis of V-series nerve agents. Exposure Hazards... [Pg.93]

Presently available methods to diagnose and biomonitor exposure to anticholinesterases, e.g., nerve agents, rely mostly on measurement of residual enzyme activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in blood. More specific methods involve analysis of the intact poison or its degradation products in blood and/or urine. These approaches have serious drawbacks. Measurement of cholinesterase inhibition in blood does not identify the anticholinesterase and does not provide reliable evidence for exposure at inhibition levels less than 20 %. The intact poison and its degradation products can only be measured shortly after exposure. Moreover, the degradation products of pesticides may enter the body as such upon ingestion of food products containing these products. [Pg.22]

Methods are also available to measure degradation products of hexachloroethane in environmental samples, but these products (e.g., tetrachloroethylene) are released to the environment from many other sources and are therefore not useful determinants of the environmental impact of this chemical. [Pg.143]


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See also in sourсe #XX -- [ Pg.738 ]




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