Decision Site

Fig. 6.7 Visualization of HTS data using Spotfire decision site [48]. Shown are a table of data (top left), a bar chart (top right, number of compounds screened from each plate), 3-D scatterplot (bottom left, percent inhibition in the primary assay versus percent inhibition in the confirmation assay versus percent purity), and a plate map (bottom right, well versus Column arranged by plate number). In the 3-D scatterplot and the plate map, the points are colored by plate number and sized by percent inhibition in the primary assay.

Synchronizing Supply Chain and Product Development Decisions Site SI Site S2 Site S3... 

Once the objectives of the well are clear, further decisions have to be made. One decision will be where to site the drilling location relative to the subsurface target and which type of rig to use. 

Information supplied by flaw visualization systems has decisive influence on fracture assessment of the defect. Results of expert ultrasonic examination show that in order to take advantage of AUGUR4.2 potentialities in full measure advanced methods of defect assessment should be applied using computer modelling, in-site data of material mechanical properties and load monitoring [4]. 

The most important chemical reaction of chi orohydrin s is dehydrochloriaation to produce epoxides. In the case of propylene oxide. The Dow Chemical Company is the only manufacturer ia the United States that still uses the chlorohydrin technology. In 1990 the U.S. propylene oxide production capacity was hsted as 1.43 x 10 t/yr, shared almost equally by Dow and Arco Chemical Co., which uses a process based on hydroperoxide iatermediates (69,70). More recentiy, Dow Europe SA, aimounced a decision to expand its propylene oxide capacity by 160,000 metric tons per year at the Stade, Germany site. This represents about a 40% iacrease over the current capacity (71). 

Table 9-51 fflves typical values of such factors for carbon steel installations taken from the data of D. R. Woods Financial Decision Making in the Process Industiy, Prentice Hall, Englewood Cliffs, NJ, 1975, p. 184). Auxiliaries and site preparation are given as factors of the delivered-equipment cost in Table 9-51, whereas C. A. Miller [Chem. 

Site Size Most MF processes require a smaller footprint than competing processes. Reduction in total-area reqmremeuts are sometimes a decisive economic advantage for MF. It may be apparent that... 

For some products, a decision may need to be made whether samples of product lots produced by a toller will be maintained at their site or returned to the client company. Certain samples may become hazardous waste, with associated disposal costs, when the sample retention time expires. When samples are held on behalf of the other party, ultimate disposal agreements should be in place. 

In choosing a site for protection installations for steel-water structures, decisive factors are the location in the harbor area and the need to keep the lengths of cable to the protected object and anode as short as possible where very high protection currents are involved. 

Figure 16-1 and 16-2 present the decision networks that guide contaminant release screening analysis. Figure 16-1 deals with contaminants in or under the soil and Fig. 16-2 addresses aboveground wastes. Any release mechanisms evident at the site will require a further screening evaluation to determine the likely environmental fate of the contaminants involved. 

Site Conditions. If the licensor s package is at the custom design stage, it is important to review the site conditions to be used in the calculations. Weather data is available for most proposed sites or at least for areas not far away. Decisions are necessary as to how to apply the weather data for example, w hether to use 95% or 99%... 

The lysis-lysogeny decision depends upon which of the two promoters in the operator region is able to bind polymerase, and that, in turn, depends upon the binding of the Cro and repressor proteins to three binding sites—ORl, OR2, and OR3—in OR. These binding sites are situated in the middle of the operator in such a way that ORl and OR2 overlap the promoter... 

The local person responsible for all decisions relating to the management of the incident. TTie Incident Commander Is in charge at the incident site. 

Early in the Corrective Action process, a decision may be made concerning whether or not containment is necessary to protect human health and the environment (HHE). If the release or threatened release presents danger to HHE, immediate action must be taken to halt migration. Under these circumstances, actions termed "Interim Measures" may be required, and excavation or containment measures may be directed by the regulatory agency. However, the Owner/Operator will be responsible for their implementation. In the event that containment is not required as an interim measure, containment may still be needed as part of the overall Corrective Action to halt the pollution migration if wastes or contaminants are to be left on-site. 

Plant designs should be based on a risk assessment that considers the process and the site in detail as well as all of the principles of inherently safer operation. Earlier decisions may limit the options in... 

A company produced bromine in Arkansas and brominated compounds in New Jersey. A risk assessment resulted in a recommendation to consider the transfer of the bromination processes to the bromine production site in Arkansas. Economics and the decrease in risk justified such a transfer and it was done. Although safety was not the only consideration, it was an important factor in this decision. 

Professional judgment should be exercised when planning site activities and to document decisions. HAZWOPER is a performance-based standard that emphasizes hazard analyses at all stages. It encourages the development of programs that match the anticipated risk for each work activity. Eor example, professional judgment is used to decide if a comprehensive HASP or a scaled-down version is required for activities with little possibility to cause significant exposure. 

The next step is to talk to individual task managers or others who can expect to perform the work. This may include subcontractors or other personnel who will perform work on the site. If contractors are involved, a decision should be made as to the relationship and responsibility for overall safety responsibility. If the HASP is likely to be adopted by others, this should be kept in mind during development. 

Provide a reasonable risk-based framework for making decisions regarding nuclear plani design, operation, and siting. 

When used to identify and evaluate significant risk contributors, as well as to assess the consequences of accident sequences, the PSA provides a comprehensive framework for making many types of decisions regarding reactor design, operation, and siting. These and other appi ications can be facilitated by the rational evaluation of the risks associated with a particular installation. 

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