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Intraocular implants

In the case of a novel product such as an intraocular implant, considerable discussion is included in the EPAR concerning the development, manufacture, and control of the product. In the particular case of one product,... [Pg.663]

Ganciclovir intraocular implant plus valganddovir 900 mg once daily until immune recovery from ART (Al)° Ganciclovir 5 mg/kg IV every 12 hours or foscarnet 180 mg/kg/day in two or three divided doses IV for 21 to 28 days (Bll)... [Pg.459]

Intraocular implant CMV retinitis treatment 4.5 mg every 5-8 months... [Pg.1072]

Ganciclovir may be administered intravenously, orally, or via intraocular implant. The bioavailability of oral ganciclovir is poor. Cerebrospinal fluid concentrations are approximately 50% of those in serum. The elimination half-life is 4 hours, and the intracellular half-life is prolonged at 16-24 hours. Clearance of the drug is linearly related to creatinine clearance. Ganciclovir is readily cleared by hemodialysis. [Pg.1072]

Intraocular implant (Vitrasert) 4.5 mg ganciclovir/implant Idoxuridine (Herplex)... [Pg.1089]

Ganciclovir may be administered intravenously, orally, or via intraocular implant. [Pg.1124]

In patients with an intraocular implant, ganclovir is released into the vitreous cavity at a rate of... [Pg.1124]

The primary potential adverse effects associated with the intraocular implant are vitreous... [Pg.1126]

Intraocular drag delivery is more difficult to achieve practically. Research, as described below, is concentrating on the development of intravitreal injections and the use of intraocular implants to improve... [Pg.300]

Bourges JL, Bloquel C, Thomas A, et al. Intraocular implants for extended drug delivery therapeutic applications. Adv Drug Deliv Rev 2006 July 31. [Pg.36]

Figure 3-19 Cross-section of ganciclovir implant. (Modified from Charles NC, Steiner GC. Ganciclovir intraocular implant. A cHnicopathologic study. Ophthalmology 1996 103 416-421.)... Figure 3-19 Cross-section of ganciclovir implant. (Modified from Charles NC, Steiner GC. Ganciclovir intraocular implant. A cHnicopathologic study. Ophthalmology 1996 103 416-421.)...
In a rare cytomegalovirus comparison trial, a ganciclovir insert (an intraocular implant) plus oral ganciclovir was compared with intravenous cidofovir (18). Based on data from 61 patients (the trial was stopped early owing to low recruitment), cidofovir was associated with a raised serum creatinine concentration of 142 pmol/l (1.6 mg/dl) or greater (0.48 per person-year), 3+ or greater proteinuria (0.29 per person-year), uveitis (0.35 per person-year), and neutropenia (0.11 per person-year). [Pg.772]

Intraocular implants for treatment of diseases of the posterior segment have been described in the section Delivery to the Vitreous and Posterior Segment. ... [Pg.170]

To evaluate the pharmacokinetics of CNTF in the vitreous humor when delivered via intraocular implantation of NT-501 as well as the long-term function of the NT-501 after implantation, capsules were implanted into rabbit eyes. At different time points after implantation, capsules were explanted and vitreous samples harvested. The CNTF output from the explanted capsules and CNTF levels in vitreous samples were determined by ELISA. [Pg.120]

Figure 9 Time course of CNTF output (after explanting) and vitreous CNTF levels after NT-501 intraocular implantation in rabbits. Abbreviation CNTF, ciliary neurotropic factor. Source From Ref. 33. Figure 9 Time course of CNTF output (after explanting) and vitreous CNTF levels after NT-501 intraocular implantation in rabbits. Abbreviation CNTF, ciliary neurotropic factor. Source From Ref. 33.
Several different intraocular drug delivery systems using biodegradable polymers such as microspheres (5-9), intraocular implants (10-13), scleral plugs (3,4,14-22), and intrascleral implants (23) have been developed. [Pg.177]

Balazs EA, Miller D, Stegmann R. Viscosurgery and the use of Na-hyaluro-nate in intraocular lens implantation. In International Congress and First Film Festival on Intraocular Implantation, Cannes, France, 1979 l-6. [Pg.326]

Bourges, J.L. Bloquel, C. Thomas, A. Fronssart, F. Bochot, A. Azan, F. Gnrny, R. BenEzra, D. Behar-Cohen, F. Intraocular implants for extended drug delivery Therapeutic applications. Adv. Drug Deliv. Rev. 2006, 58 (11), 1182-1202. [Pg.1217]

Hultsch E. The scope of hyaluronic acid as an experimental intraocular implant. Ophthalmology 1980 87 706-712... [Pg.139]

Smith KD, Burt WL. Fluorescent viscoelastic enhancement. J Cataract Refract Surg 1992 18 572-576 Smith SG, Lindstrom RL, Miller RA, Hazel S, Skelnik D, Williams P, Mindrup E. Safety and efficacy of 2% methylcellulose in cat and monkey cataract-implant surgery. J Am Intraocular Implant Soc 1984 10 160-163... [Pg.144]

See other pages where Intraocular implants is mentioned: [Pg.446]    [Pg.411]    [Pg.333]    [Pg.1072]    [Pg.1073]    [Pg.1126]    [Pg.1154]    [Pg.315]    [Pg.36]    [Pg.321]    [Pg.30]    [Pg.1481]    [Pg.2267]    [Pg.112]    [Pg.332]    [Pg.333]    [Pg.335]    [Pg.335]    [Pg.341]    [Pg.343]    [Pg.326]    [Pg.1181]    [Pg.66]    [Pg.1220]   
See also in sourсe #XX -- [ Pg.349 , Pg.350 ]

See also in sourсe #XX -- [ Pg.170 ]



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