Immune recovery uveitis

Cidofovir Uveitis (vs. immune-recovery uveitis) ( probable )... 

Ongoing treatment of healed cytomegalovirus retinitis after immime recovery does not appear to protect against the development of immune recovery uveitis.The risk is so significant that some recommend that other antiviral treatments for cytomegalovirus retinitis be substituted for cidofovir. 

Song MK, Azen SP, Buley A, et al. Effect of anti-cytomegalovirus therapy on the incidence of immune recovery uveitis inAIDS patients with healed cytomegalovirus retinitis. Am J Ophthalmol 2003 136 696-702. 

Highly probable uveitis (related to immune-recovery uveitis, or IRU), hypotony, macular edema, preretinal macular gliosis. Uveitis seen especially if i.v. cidofovir has been administered previously. Recurrences are common and VL is more significant than that due to CMV retinitis alone. 

Robinson MR, Reed G, Csaky KG, Polis MA, Whitcup SM. Immune-recovery uveitis in patients with cytomegalovirus retinitis taking highly active antiretroviral therapy. Am J Ophthalmol 2000 130 49-56. 

Kuppermann BD, Holland GN. Immune recovery uveitis. Am J Ophthalmol 2000 130 103-106. 

Karavellas MP, Song M, Macdonald JC, Freeman WR. Long-term posterior and anterior segment complications of immune recovery uveitis associated with cytomegalovirus retinitis. Am J Ophthalmol 2000 130 57-64. 

Viral retinitis may be caused by herpes simplex virus, cytomegalovirus (CMV), adenovirus, and varicella zoster virus. With the highly active antiretroviral therapy (see Chapter 50), CMV retinitis does not appear to progress when specific anti-CMV therapy is discontinued, but some patients develop an immune recovery uveitis. Treatment usually involves long-term parenteral administration of antiviral drugs. Intravitreal administration of ganciclovir has been found to be an effective... 

KaraveUas MR Azen SR MacDonald JC, et al. Immune recovery vitreitis and uveitis inAIDS. Clinical predictors, sequelae, and treatment outcomes. Retina 2001 21 1. 

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