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Cysteine treatment

Amarnth and Amamth [15] described a specific method for the determination of penicillamine and cysteine. Treatment with 1,1-thiocarbonyl diimidazole converts penicillamine to 5,5-dimethyl-2-thioxothiazolidine-4-carboxylic add. The detection limit is 2 pmol of the drug per injection, and the detector response is linear up to 1 nmol. [Pg.135]

Oxidation of Cysteines. Treatment of a protein with performic acid cleaved all the disulfide bonds and converted all Cys residues to cysteic acid residues (Fig. 3-26). [Pg.41]

Standard cardiorespiratory resuscitation and antiarrhythmia treatment are used for acute solvent poisoning. Toxicity from carbon tetrachloride and chloroform involves the generation of phosgene (a 1914-18 war gas) which is inactivated by cysteine, and by glutathione which is formed from cysteine treatment with N-acetylcysteine, as for poisoning with paracetamol, is therefore recommended. [Pg.160]

R. Kirscherf. T. Fischbach, S. Mihm, S. Roth, E. Hohenhaus-Sievert, C. Weiss, L. Edler, P. Bartsch and W. Droge. Effect of Glutathione Depletion and Oral N-Acetyl-Cysteine Treatment on Cd4+ and Cd8+ Cells, Faseb J 8 (1994) 448-451. [Pg.110]

HIV-positive people lose large amounts of sulfur via the urine, and this is accompanied by a low sulfur (especially cysteine and glutathione) concentration in the blood serum. Sulfur excretion was more than three-fold higher than in HIV-negative patients. In addition to an increased cysteine level following N-acetylcysteine and cysteine treatment, an improvement in immune function has also been observed (Breitkreuz et al. 2000). [Pg.1311]

Cysteine is used as a reductant for cold wave treatment in place of thioglycoHc acid. A/-Lauroylarginine ethyl ester [48076-74-0] is appHed as the hydrochloride as a preservative. Urocanic acid [104-98-3] hich. is derived from histidine is used in skin cream as a uv absorber (235). [Pg.297]

Woodward s total synthesis of cephalosporin C begins with L-cysteine (48) which establishes the chiral center at C-7. The cis geometry at C-6,7 is achieved in intermediate (49) which is cyclized to (50) by treatment with triethylaluminum. The dihydrothiazine ring is constructed by Michael addition to the condensation product of trichloroethyl glyoxylate... [Pg.294]

These sulfides are prepared from other sulfur-protected cysteine derivatives by reaction with the sulfenyl chloride, The Npys group can also be introduced directly by treatment of the thiol with NpysCl, ... [Pg.489]

The simplest NHIP is rubredoxin, in which the single iron atom is coordinated (Fig. 25.9a) to 4 S atoms belonging to cysteine residues in the protein chain. It differs from the other Fe-S proteins in having no labile sulfur (i.e. inorganic sulfur which can be liberated as H2S by treatment with mineral acid sulfur atoms of this type are not part of the protein, but form bridges between Fe atoms.)... [Pg.1102]

The naturally occurring form of the amino acid cysteine (Problem 9.48) has the S configuration at its chirality center. On treatment with a mild oxidizing agent, two cysteines join to give cystine, a disulfide. Assuming that the chirality center is not affected by the reaction, is cystine optically active ... [Pg.326]

The use of CA inhibitors as diuretics is limited by their propensity to cause metabolic acidosis and hypokalemia. Their use can be indicated in patients with metabolic alkalosis and secondary hyperaldosteronism resulting for example from aggressive use of loop diuretics. Furthermore, CA inhibitors are effective dtugs to produce a relatively alkaline urine for the treatment of cysteine and uric acid stones as well as for the accelerated excretion of salicylates. Perhaps the most common use of CA inhibitors is in the treatment of glaucoma. [Pg.431]

The Strecker reaction has been performed on the aldehyde 182 prepared from L-cysteine [86] (Scheme 28). The imine was formed in situ by treatment with benzylamine, then TMS cyanide was added to afford prevalently in almost quantitative yield the syn-diamine 183, which is the precursor of (-l-)-biotin 184. The syn selectivity was largely affected by the solvent, toluene being the solvent of choice. Since the aldehyde 182 is chemically and configurationally unstable, a preferred protocol for the synthesis of 183 involved the prehminary formation of the water-soluble bisulfite adduct 185 and the subsequent treatment with sodium cyanide. Although in this case the syn selectivity was lower, both diastereomers could be transformed to (-l-)-biotin. [Pg.33]

Chemical modifications like alkylation with (A-ethylmaleimide (NEM) or oxidation with diamide that inhibit the phosphorylation activity of the enzyme did not seem to have any significant effect on the high affinity binding site when the enzyme was solubilized in the detergent decyl-PEG [69,41]. However, in the intact membrane these treatments reduced the affinity by a factor of 2-3. The reduction of the affinity was exclusively due to modification of the cysteine residue at position 384 in the B domain [69]. Apparently, the detergent effects the interaction between the B and C domains. [Pg.149]

As a more sensitive detection method, MS can be very useful in amino acid determinations. For example, S-carboxymethyl-(R) cysteine or SCMC, is a mucolytic agent used in the treatment of respiratory diseases. The development of a method utilizing high performance IEC and atmospheric pressure ionization (API) mass spectrometry to quantify SCMC in plasma has been described.66 This method is simple (no derivatization needed), rapid (inn time 16 min.), sensitive (limit of quantification 200 ng/mL in human plasma), and has an overall throughput of more than 60 analyses per day. API-MS was used successfully with IEC to determine other sulfur-containing amino acids and their cyclic compounds in human urine.67 IEC has also been used as a cleanup step for amino acids prior to their derivatization and analysis by gas chromatography (GC), either alone or in conjunction with MS.68 69... [Pg.291]


See other pages where Cysteine treatment is mentioned: [Pg.380]    [Pg.909]    [Pg.241]    [Pg.70]    [Pg.380]    [Pg.909]    [Pg.241]    [Pg.70]    [Pg.109]    [Pg.500]    [Pg.491]    [Pg.158]    [Pg.308]    [Pg.172]    [Pg.279]    [Pg.23]    [Pg.131]    [Pg.456]    [Pg.368]    [Pg.96]    [Pg.22]    [Pg.10]    [Pg.332]    [Pg.1278]    [Pg.1295]    [Pg.853]    [Pg.362]    [Pg.245]    [Pg.85]    [Pg.286]    [Pg.320]    [Pg.853]    [Pg.146]    [Pg.154]    [Pg.156]    [Pg.255]    [Pg.181]    [Pg.188]    [Pg.339]    [Pg.352]    [Pg.258]   
See also in sourсe #XX -- [ Pg.280 ]

See also in sourсe #XX -- [ Pg.280 ]




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