Solubilization cyclodextrins

Loftsson, T., A. Magnusdottir, M. Masson, and J. F. Sigurjonsdottir (2002). Self-association and cyclodextrin solubilization of drugsJ. Pharm. Sci., 91 2307-2316. 

Duan, M. S., Zhao, N., Oessurardottir, I. B., Thorsteinsson, T., and Loftsson, T. 2005. Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban formation of aggregates and higher-order complexeslnt. J. Pharm. 297 213-222. 

Loftsson, T. and Masson, M. 2004. The effects of water-soluble polymers on cyclodextrins and cyclodextrin solubilization of drugsJ. Drug Delivery Sci. Technol. 14 35-43. 

Calculate the amount of cyclodextrin-solubilized drug spectro-photometrically, by measuring its absorption at 256 nm, and constructing an appropriate calibration curve, ftom solutions of known drug concentration. 

Quitschke WW, Steinhauff N, Rooney J (2013) The effect of cyclodextrin-solubilized curcuminoids on amyloid plaques in Alzheimer transgenic mice Brain uptake and metabolism after intravenous and subcutaneous injection. Alzheimers Res Ther 5 16... 

Cited by Loftsson T, Gudmundsdottir H, Sigurjonsdottir JF, Sigurdsson JH, Sigfusson SD, Masson M and Steffanson E, Cyclodextrin solubilization of benzodiazepines Formulation of midazolam nasal spray, Int. J. Pharm., 212,29-40 (2001). 

N,N-Dimethyl-N-lauric acid-amidopropyl-N-(3-sulfopropyl)-ammonium betaine N,N-Dimethyl-N-myristyl-N-(3-sulfopropyl)-ammonium betaine N,N-Dimethyl-N-palmityl-N-(3-sulfopropyl)-ammonium betaine N,N-Dimethyl-N-stearyl-N-(3-sulfopropyl)-ammonium betaine N,N-Dimethyl-N-tallow-N-(3-sulfopropyl)-ammonium betaine N,N-Distearyl-N-methyl-N-(3-sulfopropyl)-ammonium betaine solubilizer, titanate 2-Dimethylamino-2-methyl-1-propanol solubilizer, tobacco Methyl-P-cyclodextrin solubilizer, topical solutions Cetylpyridiniurn chloride solubilizer, triglycerides PEG-10 olive glycerides PEG-13 sunflower glycerides... 

Teranishi, K., and Shimomura, O. (1997a). Solubilizing coelenterazine in water with hydroxypropyl-p-cyclodextrin. Biosci. Biotech. Biochem. 61 1219-1220. 

Micellar medium has received great attention because it solubilizes, concentrates and orientates the reactants within the micelle core and in this way accelerates the reaction and favors the regio- and stereoselectivity of the process [68], In addition the micellar medium is cheap, can be reused, is more versatile than cyclodextrins and more robust than enzymes. With regard to Diels Alder reactions, we may distinguish between (i) those in which one or both reagents are surfactants which make up the micellar medium, and (ii) those that are carried out in a micellar medium prepared by a suitable surfactant. 

Cyclodextrins can solubilize hydrophobic molecules in aqueous media through complex formation (5-8). A nonpolar species prefers the protective environment of the CDx cavity to the hulk aqueous solvent. In addition, cyclodextrins create a degree of structural rigidity and molecular organization for the included species. As a result of these characteristics, these macrocycles are used in studies of fluorescence and phosphorescence enhancement (9-11), stereoselective catalysis (.12,13), and reverse-phase chromatographic separations of structurally similar molecules (14,15). These same complexing abilities make cyclodextrins useful in solvent extraction. 

Szente, L. et al.. Stabilization and solubilization of lipophilic natural colorants with cyclodextrins, J. Inclusion Phen. Mol. Recognition Chem., 32, 91, 1998. 

A good deal of attention recently has been directed towards the use of derivatives of cyclodextrin for the solubilization and stabilization of pharmaceuticals [124 126]. One cautionary note—complexation may adversely affect the dissolution an/or permeability characteristics of the drug, thereby possibly decreasing drug bioavailability. 

H. Dodziuk, A. Ejchart, W. Anczewski, H. Ueda, E. Krinichnaya, G. Dolgonos, and W. Kutner, Water solubilization, determination of the number of different types of single-wall carbon nanotubes and their partial separation with respect to diameters by complexation with r/-cyclodextrin, Chem. Commun. (2003) 986-987. 

Unfortunately, the relatively low solubility of /8-cyclodextrin has precluded its widespread use as a solubilizing agent. To enhance the solubility of /8-cyclodextrin, much work has been carried out on possible derivatizations of the /8-cyclodextrin skeleton. 2-Hydroxypropyl-/3-cyclodextrin has been found to exhibit the desired enhanced solubility, while still retaining the optimal binding characteristics of underivatized /8-cyclodextrin. In addition, this derivative is relatively nontoxic and may even be used in parenteral applications [63],... 

The number of studies describing the solubilization of drug compounds by cyclodextrins is extraordinarily large, and the recent state of the field has been summarized [64,65]. 

The cyclodextrins are stable bodies in aqueous solution, unlike the micelles, which are transitory and are in a state of dynamic equilibrium with the monomer surfactants. However, in many aspects the inclusion of analytes in the cyclodextrin cavity is reminiscent of the solubilization of hydrophobic molecules in micelles in aqueous solution. 

Low affinity to polar solvents and fullerenes aggregation in water limit their use in biologic systems. To increase water solubility of fullerenes, few ways are used solubilization with the use of some water-soluble polymers like PDT or polyvin-ilpyrrolidone, generation of complexes with cyclodextrines or calixarenes, and... 

Evaluating the effect of hydroxypropyl cyclodextrine (HPCD) on phenan-threne solubilization and biodegradation, showing HPCD significantly increased the apparent solubility (i.e., the bio availability) of phenanthrene, having a major impact on the biodegradation rate of phenanthrene [193]. 

K. Abe, T. Irie, and K. Uekama. Enhanced nasal delivery of luteinizing hormone releasing hormone agonist buserelin by oleic acid solubilized and stabilized in hydroxypropyl-/S-cyclodextrin. Chem Pharm Bull 43 2232-2237 (1995). 

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