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Anionic drugs

Bouchard, G., Galland, A., Garrupt, P. A., Gulaboski, R., Mirceski, V., Scholz, F., Girault, H. H. Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes. Phys. Chem. Chem. Phys. 2003, 5, 3748-3751. [Pg.435]

J. Boylan and G. Banker. Molecular-scale drug entrapment as a precise method of controlled drug release II Entrapment of anionic drugs by polymeric gelation. J. Pharm. Sci. 62 1177-1184, 1973. [Pg.32]

Recently, molecular biology studies have been carried out on hepatic uptake transporters. With regard to the Na+-dependent hepatic uptake of bile acids, Na+-taurocholate cotransporting polypeptide (Ntcp/NTCP) has been cloned from both rodents and humans [14-17]. Ntcp/NTCP accepts bile salts, such as taurocholate and glycocholate, as well as some anionic compounds such as dehydroepian-drosterone sulfate and bromosulfophthalein [16, 18]. However, the presence of unidentified Na+-dependent transporters for anionic drugs (e.g., bumetanide) has also been suggested [19, 20]. [Pg.289]

Y. Sakurai, H. Motohashi, H. Ueo, S. Masuda, H. Saito, M. Okuda, N. Mori, M. Matsuura, T. Doi, A. Fukatsu, O. Ogawa, and K. Inui. Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res 21 61-67 (2004). [Pg.574]

Y. Ozeki, Y. Kurono, T. Yotosuyanagi, K. Ikeda, Effects of Drug Binding on the Esterase Activity of Human Serum Albumin Inhibition Modes and Binding Sites of Anionic Drugs , Chem. Pharm. Bull. 1980, 28, 535-540. [Pg.96]

Plasma protein binding is also an important parameter in the pharmacokinetic field. Frontal analysis combined with capillary zone electrophoresis (CZE-FA) (67-69) is a powerful technique for high-throughput assay, because it is relatively rapid and easy to automate, in comparison with conventional methods such as dialysis, ultrafiltration, and ultracentrifugation. Recently, we introduced the EKC approach with ionic CDs to frontal analysis for anionic drugs that cannot be analyzed by conventional CZE-FA (70). In this approach, ionic CDs work as an EKC pseudostationary not for proteins but for small solutes. [Pg.78]

The drug designer may do well to provide internal charge compensation, rather than to seek a salt formulation when faced with a strongly cationic or anionic drug candidate. A good example of this ploy comes from the work... [Pg.72]

Z Uptake of bilirubin by the liven Bilirubin is only slightly soluble in plasma and, therefore, is transported to the liver by binding non-covalently to albumin. [Note Certain anionic drugs, such as salicylates and sulfonamides,1 can displace bilirubin from abu-min, permitting bilirubin to enter the central nervous system (CNS). This causes the potential for neural damage in infants.] Bilirubin dissociates from the carrier albumin molecule and enters a hepatocyte, where it binds to intracellular proteins, particularly the protein ligandin. [Pg.280]

Loftsson, T., Leeves, N., Sigurjonsdottir, J. F., Sigurosson, H. H., and Masson, M. 2001. Sustained drug delivery system based on a cationic polymer and an anionic drug/cyclodextrin corfiftemazie. [Pg.157]

Azone (laurocapram) is used extensively as a transdermal permeation enhancer, and has also found use in buccal drug delivery. It is a lipophilic surfactant in nature (Figure 10.4). Permeation of salicylic acid was enhanced by the pre-application of an Azone emulsion in vivo in a keratinized hamster cheek pouch model [35]. Octreotide and some hydrophobic compounds absorption have also been improved by the use of Azone [36], Azone was shown to interact with the lipid domains and alter the molecular moment on the surface of the bilayers [37], In skin it has been proposed that Azone was able to form ion pairs with anionic drugs to promote their permeation [38],... [Pg.208]

Yabuuchi H, Tamai I, Morita K, et al. Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Nptl. J Pharmacol Exp Ther 1998 286 1391-1396. [Pg.191]

The effect of different polymer bases and additives on percutaneous absorption of these two ionic drugs are examined. Carboxyvinylpolymer (CVP), an ionic polymer film base, yields films with poor bioavailability of cationic drugs such as DIL, but is effective for films containing anionic drugs such as DSCG. In contrast, polyvinyl alcohol (PVA) and glycerol, electrically neutral bases, were used to formulate films with good bioavailability. [Pg.273]

The interactions of many important drugs, metabolites, and structurally related compounds with HSA have been char-acterized on the basis of their inhibition of its acetylation by p-nitrophenyl acetate. Dissociation constants of 10 5M or lower have been determined for tryptophan, phenylpyru-vate, several pharmacologically important benzodiazepines, several types of small, apolar, anionic drugs and related compounds that interact specifically with the inhibitory site. Two other classes of inhibitory compounds have been identified and similarly characterized, the members of which interact either to a comparable extent or preferentially with one other site. The inhibitory site appears to be elongated, apolar, and has a monoanion binding site near one end. [Pg.320]


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See also in sourсe #XX -- [ Pg.118 , Pg.138 ]

See also in sourсe #XX -- [ Pg.208 ]




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