Cyclin-dependent protein kinases CDKs domains

CAT-REL, vesicular catecholamine release CB-R, cannabinoid receptor CB1-R, CB2-R, cannabinoid receptors CBD, chitin-binding domain CBG, cortisol-binding globulin CBZ-R, central benzodiazepine receptor CCK-R, cholecystokinin receptor CDC, chrysanthemum dicarboxylic acid CDK, cell division kinase, cyclin-dependent protein kinase... 

Another simple approach for the detection of noncovalent interactions is to compare the peptide maps produced by proteolysis of the target protein and its complex with other ligands. This approach, also known as epitope mapping, relies on the fact that the two maps differ qualitatively because the contact regions of the interacting proteins are shielded from the protease s activity in the complex. An illustrative example is the detection of protein-protein interaction between a protein representing the kinase inhibitory domain of the cell cycle regulatory protein (p21-B) and cyclin-dependent kinase 2 (cdk).164... 

The C-terminal domain (CTD) of the largest subunit in RNA Pol II plays an important role in the function of Mediator (Myers and Kornberg, 2000). The domain, which consists of multiple heptapeptide repeats of the sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser, is conserved in all eukaryotes studied to date. In. S , cerevisiae, CTD truncations cause defects in transcriptional activation both in vivo and in vitro (Scafe et al., 1990). Two distinct forms of RNA pol II have been identified in S. cerevisiae. Most RNA Pol II molecules have an unphosphorylated CTD, but a portion of RNA Pol II molecules is highly phosphorylated. The unphosphorylated RNA Pol II associates with the promoter-bound initiation complex, whereas the phosphorylated form is responsible for active elongation (Cadena and Dahmus, 1987). The principal protein kinase involved in the phosphorylation of CTD has been identified as Kin28, a cyclin dependent kinase (cdk) and subunit of... 

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