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Tumor suppressor genes cyclin dependent kinase inhibitors

Fig. 18.8. Control of the Gl/S transition in the cell cycle. The genes encoding cyclins and CDKs are oncogenes, and the gene encoding the Retinoblastoma protein (Rb) is a tumor suppressor gene. Abbreviations CDK, cyclin- dependent kinase CDKI, cyclin-dependent kinase inhibitor. Fig. 18.8. Control of the Gl/S transition in the cell cycle. The genes encoding cyclins and CDKs are oncogenes, and the gene encoding the Retinoblastoma protein (Rb) is a tumor suppressor gene. Abbreviations CDK, cyclin- dependent kinase CDKI, cyclin-dependent kinase inhibitor.
AID-induced c-myc translocation, miR-155 acts as a tumor suppressor microRNA [335, 336]. The promoter gene of miR-124-1 in chromosome 8p is frequently methylated (silenced) in human malignant lymphoma cells, including those of NK/T lymphoma cells. The miR-124-2 is a direct inhibitor of the CDK6 cyclin-dependent kinase mRNA [337]. Moderate and pronounced anti-AID mRNA activity is exerted by miR-155 and miR-93, respectively [338]. [Pg.115]

See other pages where Tumor suppressor genes cyclin dependent kinase inhibitors is mentioned: [Pg.643]    [Pg.579]    [Pg.643]    [Pg.105]    [Pg.924]    [Pg.354]    [Pg.362]    [Pg.573]    [Pg.64]    [Pg.67]    [Pg.164]    [Pg.2282]    [Pg.116]    [Pg.126]    [Pg.429]    [Pg.309]   


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Cyclin

Cyclin dependent kinase inhibitors

Cyclin-dependant kinase inhibitor

Cyclin-dependant kinases

Cyclin-dependent

Cycline-dependent kinases

Cyclins

Cyclins cyclin

Inhibitors tumor

Kinase inhibitors

Kinase, kinases inhibitors

Suppressor genes

Suppressors

Tumor suppressors

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