CRADAs agreements

D. R. James, Technical Note No. 1, Cooperative Research and Development Agreement (CRADA), Investigation of S2p Q Production and Mitigation in... 

Cooperative Research and Development Agreement. A CRADA is designed to involve industrial and government labs in cooperative research programs. A CRADA typically has provisions for sharing technical resources, protecting confidentiality, and treatment of intellectual property. The subject CRADA was sponsored by the US Department of Energy (DOE). 

Recent advances in biotechnology have resulted in improved fermentation processes for the production of useful chemical intermediates. One such process was developed a few years ago during the U.S. DOE sponsored CRADA (Cooperative Research and Development Agreement) with Applied Carbochemicals (ACC). Under this CRADA a consortium of four national labs including Argonne National Laboratory (ANL), Oak Ridge National Laboratory (ORNL), National Renewable Energy Laboratory (NREL), and Pacific... 

In 1992, LANL and the Electric Power Research Institute (EPRI) entered into a cooperative research and development agreement (CRADA) to transfer SDP to industry. Through a competitive call for proposals. High Mesa Technologies, L.L.C. (HMT) of Santa Fe, New Mexico, subsequently was selected as the third partner to commercialize and develop SDP equipment. HMT has also licensed the rights to use SDP technology for process off-gas control. In February 1997, it was reported that HMT was seeking opportunities to demonstrate a commercial SDP system for industrial off-gas treatment and anticipated that commercial units would be available in 12 to 18 months. 

Much of the basis of the BMS CRADA proposal was built on the ability of BMS to tap into the tremendous synthetic knowledge contained in Robert Holton s research group at Florida State University (FSU). This research group had been actively studying the chemistry of Taxol and had made significant strides toward a total synthesis and a viable semi-synthetic pathway from 10-DAB. A licensing agreement between BMS and FSU was created, and in 1992 the first commercially viable semi-synthetic route from 10-DAB to Taxol was discovered [13]. 

More importantly, the FDA has been instrumental in the release of data and information from regulatory submissions. Matthews and Contrera (1998) report the development of MultiCASE for the prediction of carcinogenicity using data released from the FDA under a Cooperative Research and Development Agreement (CRADA). The model developed with the FDA data had greatly... 

Intellectual property issues need to be addressed more effectively. In the past, collaborations typically involved a company and a federal laboratory. Simple assignments of the patents or provisions for the company to license the technology were adequate. The DOE cooperative research and development agreement (CRADA) Subject Invention definition can confuse intellectual property ownership. Today, the collaborations may involve several partners, the results may be used by joint ventures, or even more-creative business structures may need access to the intellectual property developed by the collaboration. Increased flexibility on how this property is managed is a key issue for the future. 

Should a compound show promising anticancer activity in the routine screening operations, the NCI may propose the establishment of a more formal collaboration, such as a Cooperative Research and Development Agreement (CRADA) or a Clinical Trial Agreement (CTA) (see NCI Technology Development and Commercialization Branch Website http //tdcb.nci.nih.gov). 

Under a Cooperative Research and Development Agreement (CRADA) between FDA and MultiCASE, new database modules have been developed for MCASE that contain an expanded training-set of compounds representing proprietary compounds from chemicals submitted to the agency for review and some mutagenic compounds that failed during development at pharmaceutical companies [27,28]. 

CRADA Cooperative Research and Development Agreement (with NIH)... 

Most importantly, the legislation permits the establishment of formal cooperative research and development agreements (CRADAs) in which a Federal laboratory provides personnel, services, facilities, equipment or resources (but not funds), and a non-Federal party (e.g., a private company) provides finds, personnel, services, facilities, equipment or other resources for R D. 

KEY ADAM HA- Alcohol Drug Abuse and Mental Health Administration CRADAs - cooperative research and development agreements NIH - National Institutes of Health. 

ADAMHA (table 9-7). An OTA analysis of CRADAs in effect in October 1990 in PHS (NIH, ADAMHA, CDC, and FDA) shows that CRADAs were heavily concentrated in the National Cancer Institute, which had 26 percent of all such agreements at that time (table 9-8). 

KEY AIDS - acquired immunodeficiency syndrome. CRADAs. cooperative research and development agreements HIV - human immunodeficiency virus. NCI - National Cancer Institute. PHS-Public Health Service. PMA - Pharmaceutical Manufacturer... 

Conversely, could CRADAs eventually turn NIH into little more than a giant contract lab if companies lure NIH scientists into cooperative agreements that serve the companies need for NIH brain power at the... 

Cooperative Research and Development Agreements (CRADA) A formal agreement between a Federal laboratory and anon-Federal party (individual, university, or private firm) in which the non-Federal party provides resources in exchange for exclusive rights to license patents that result from the collaboration. Congress gave Federal laboratories the authority to enter into CRADAs as part of the Federal Technology Transfer Act of 1986 (Public Law 99-502). 

Accomplishments under CRADA — US DOE sponsored a Cooperative Research and Development Agreements (CRADA) from 1994 to 1997 in which ORNL, Sandia National Laboratory and ten industrial partners collaborated. There have been numerous noteworthy development programmes involving electron beam curable composites until 2000s [11],... 

Not only academic labs, but also government ones can be involved. Sometimes, researchers at the National Institutes of Health (NIH) can be interested in the experimental use of tool compounds that a biotech or pharma company may have. Rather than an MTA, the contract covering such a transfer will probably be what s called a materials cooperative research and development agreement, or materials CRADA As in the case of academia, more of a true... 

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