CRADA

D. R. James, Technical Note No. 1, Cooperative Research and Development Agreement (CRADA), Investigation of S2p Q Production and Mitigation in... 

U.S. Environmental Protection Agency, "EPA and Industry Sign CRADA to Develop Iimovative Lasagna Process," in Bioremediation in the Field, Center for Environmental Research Information, Cincinnati, Ohio, 1994. 

An analogous mechanism should also produce polymers on irradiation of epoxies. Crivello s recent mechanistic suggestions [29] are consistent with the mechanisms given above. One can conclude that radiation-induced polymerization of epoxies can proceed via several mechanisms. However, further work is needed to determine the relative contributions of the different mechanisms, which might vary from one epoxy to another. As part of the Interfacial Properties of Electron Beam Cured Composites CRADA [37], an in-depth study of the curing mechanism for the cationic-initiated epoxy polymerization is being undertaken. 

Cooperative Research and Development Agreement. A CRADA is designed to involve industrial and government labs in cooperative research programs. A CRADA typically has provisions for sharing technical resources, protecting confidentiality, and treatment of intellectual property. The subject CRADA was sponsored by the US Department of Energy (DOE). 

CRADA, ORNL99-0544, Interfacial Properties of Electron Beam Cured Composites, 1999. Klein, A.J., Repair of eomposites. Adv. Composites, June/July, p. 50 (1987). 

I mentioned that the automotive composites consortium is working with NIST, under one of the CRADAs. CRADA once an obscure acronym, has become very popular in Washington, DC. If federal research initiatives are to be fully successful, the results of this research must be transferred to industry, where they can form the basis for new and enhanced products and processes. Traditional mechanisms exist (such as contracts, patent licensing, and the like), but I don t think any of them are quite as powerful as the CRADA... 

Recent advances in biotechnology have resulted in improved fermentation processes for the production of useful chemical intermediates. One such process was developed a few years ago during the U.S. DOE sponsored CRADA (Cooperative Research and Development Agreement) with Applied Carbochemicals (ACC). Under this CRADA a consortium of four national labs including Argonne National Laboratory (ANL), Oak Ridge National Laboratory (ORNL), National Renewable Energy Laboratory (NREL), and Pacific... 

D. C. Elliott, Final Report CRADA with Int. Polyol Chemicals Inc. and Pacific Northwest National Laboratory Process Optimization for Polyols Production from Glucose, PNNL-11476, Pacific Northwest National Laboratory, Richland, Washington, 1997. 

In 1992, LANL and the Electric Power Research Institute (EPRI) entered into a cooperative research and development agreement (CRADA) to transfer SDP to industry. Through a competitive call for proposals. High Mesa Technologies, L.L.C. (HMT) of Santa Fe, New Mexico, subsequently was selected as the third partner to commercialize and develop SDP equipment. HMT has also licensed the rights to use SDP technology for process off-gas control. In February 1997, it was reported that HMT was seeking opportunities to demonstrate a commercial SDP system for industrial off-gas treatment and anticipated that commercial units would be available in 12 to 18 months. 

Much of the basis of the BMS CRADA proposal was built on the ability of BMS to tap into the tremendous synthetic knowledge contained in Robert Holton s research group at Florida State University (FSU). This research group had been actively studying the chemistry of Taxol and had made significant strides toward a total synthesis and a viable semi-synthetic pathway from 10-DAB. A licensing agreement between BMS and FSU was created, and in 1992 the first commercially viable semi-synthetic route from 10-DAB to Taxol was discovered [13]. 

Davison, B., Nghiem, J., Donnelly, M., and Peabody, M. (2003), CRADA Final Report no. C/ORNL/99-0552, Oak Ridge National Laboratory, Oak Ridge, TN. 

Oak Ridge National Laboratory, Argonne National Laboratory, Pacific Northwest National Laboratory, National Renewable Energy Laboratory, and Applied Carbo-chemicals, Inc. (1999), CRADA Final Report for CRADA ORNL 96-0407. 

More importantly, the FDA has been instrumental in the release of data and information from regulatory submissions. Matthews and Contrera (1998) report the development of MultiCASE for the prediction of carcinogenicity using data released from the FDA under a Cooperative Research and Development Agreement (CRADA). The model developed with the FDA data had greatly... 

CRADA) between the U.S. FDA and MultiCASE. It was designed to improve the prediction of the carcinogenic potential of pharmaceuticals. Matthews and Contrera (1998) performed a beta-test evaluation utilizing 126 compounds not included in the test database with 934 compounds. The results demonstrated an improvement in all statistical parameters for the prediction of carcinogenicity compared to the MultiCASE prediction with an overall concordance of 75 % (Patlewicz et al. 2003). 

Intellectual property issues need to be addressed more effectively. In the past, collaborations typically involved a company and a federal laboratory. Simple assignments of the patents or provisions for the company to license the technology were adequate. The DOE cooperative research and development agreement (CRADA) Subject Invention definition can confuse intellectual property ownership. Today, the collaborations may involve several partners, the results may be used by joint ventures, or even more-creative business structures may need access to the intellectual property developed by the collaboration. Increased flexibility on how this property is managed is a key issue for the future. 

Hank Whalen, PQ Corporation Are CRADAs increasing or decreasing with Dow ... 

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