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Corticotropin releasing factor effects

Rivier, J, Rivier, C, and Vale, W (1984) Synthetic Competitive Antagonists of Corticotropin-Releasing Factor Effect on ACTH Secretion in the Rat Science 224, 889-891... [Pg.216]

Dopamine has an alerting effect. Neurochemicals involved in wakefulness include norepinephrine and acetylcholine in the cortex and histamine and neuropeptides (e.g., substance P and corticotropin-releasing factor) in the hypothalamus. [Pg.827]

Rassnick S, Heinrichs SC, Britton KT, Koob GF. 1993. Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res 605(1) 25-32. [Pg.253]

Skelton KH, Nemeroff CB, Knight DL, Owen MJ (2000) Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems. J Neurosci 20 1240-1248... [Pg.140]

Valdez GR, Inoue K, Koob GF, Rivier J, Vale WW, Zorilla EP (2002) Hiunan imocortin II mUd locomotor suppressive and delayed anxiolytic effects of a novel corticotropin-releasing factor related peptide. Brain Res 943 142-150... [Pg.140]

Isogawa K, Akiyoshi J, Hikichi T, Yamamoto Y, Tsutsumi T, Nagayama H (2000) Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo. Neuropeptides 34 234-239... [Pg.201]

Kirby LG, Chou-Green JM, Davis K, Lucki I (1997) The effects of different stressors on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res 760 218-230 Kirby LG, Rice KC, Valentino RJ (2000) Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus. Neuropsychopharmacology 22 148-162 Kozicz T, Yanaihara H, Arimura A (1998) Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. J Comp Neurol 391 1-10 Lavicky J, Dunn AJ (1993) Corticotropin-releasing factor stimulates catecholamine release in hypothalamus and prefrontal cortex in freely moving rats as assessedby microdialysis. J Neurochem 60 602-612... [Pg.201]

Ron an PJ, Kramer GL, Petty F (2001) Corticotropin releasing factor and arginine vasopressin effects in the learned helplessness animal model. Soc Neurosci Meeting Abstr 414.20 Rosen JB, Schulkin J (1998) From normal fear to pathological anxiety. Psychol Rev 105 325-350... [Pg.366]

Stogner KA, Holmes PV (2000) Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats. Eur J Pharmacol 387 R9-R10 Stout SC, Owens MJ, Nemeroff CB (2002) Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment. J Pharmacol Exp Ther 300 1085-1092 StrOhle A, Jahn H, Montkowski A, Liebsch G, Boll E, Landgraf R, Holsboer F, Wiedemann K (1997) Central and peripheral administration of atriopeptin is anxiolytic in rats. Neuroendocrinology 65 210-215... [Pg.367]

Ward HE, Johnson EA, Salm AK, Birkle DL (2000) Effects of prenatal stress on defensive withdrawal behavior and corticotropin releasing factor systems in rat brain. Physiol Behav 70 359-366... [Pg.368]

Kirby, L.G., Rice, K.C., and Valentino, R.J. (2000) Effects of corticotropin-releasing factor on neuronal activity in the seroto-... [Pg.121]

M. J. (1999b) The role of corticotropin-releasing factor—norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress. Biol Psychiatry 46 1153-1166. [Pg.134]

Effects of early environmental adversity on HPA mediation of neurodevelopment have also been demonstrated in non-human primates (Coplan et al., 1995). Corticotropin-releasing hormone (CRH) intracerebro-ventricular administration in rhesus monkeys that had been separated from their mothers produced behavioral inhibition and increases in ACTH and cortisol. Coplan et al (1995) presented evidence for persistently elevated cerebrospinal fluid concentrations of corticotropin-releasing factor (CRF) in grown macaques that had been reared by mothers in unpredictable environmental conditions. Further studies in adversely reared adult monkeys demonstrated an inverse relationship between mean CRF concentrations and GH response to clonidine (Coplan et al., 2000). In light of evidence that reduced GH response to clonidine has been shown in other anxiety disorders (Charney and Bremner, 1999), Coplan et al. (2000) hypothesize that GH response to clonidine may inversely reflect trait-like increases of central nervous system CRF activity. Data linking childhood anxiety to growth deficits are consistent with this view (Pine et al., 1996). Activity, of the HPA axis, as related to early environmental... [Pg.146]

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Corticotropin

Corticotropin-releasing

Corticotropin-releasing factor

Corticotropin-releasing factor anxiolytic effects

Release factors

Releaser effect

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