Hemoglobins, conjugated

Conjugated-diene butyl, 4 436—431 Conjugated drying oils, 9 148 Conjugated hemoglobin, 4 122-124 Conjugated linoleic acid (CLA), 10 829 17 664-665... 

A polyethylene glycol-conjugated hemoglobin derivative and carbon monoxide carrier, CO-MP4, is able to deliver CO to the circulation and reduces ischemia/ reperfusion injury in rats, providing the first evidence for this drug as a CO therapeutic agent [191, 192]. 

Nitrosylated Polyethylene Glycol-conjugated Hemoglobin Derivative as a Candidate Material for Oxygen Therapeutics... 

Jahr JS, Akha AS, Holtby RJ. Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers clinical safety and efficacy... 

Proteins may consist exclusively of a polymeric chain of amino acids these are the simple proteins. Quite often some other chemical component is covalendy bonded to the amino acid chain. Glycoproteins and Hpoproteins contain sugar and Hpid components, respectively. Porphyrins are frequently associated with proteins, eg, in hemoglobin. Proteins bound to other chemical components are called conjugated proteins. Most enzymes are conjugated proteins. 

The phthalocyanine [1-4] system is structurally derived from the aza-[18]-annulene series, a macrocyclic hetero system comprising 18 conjugated n-electrons. Two well known derivatives of this parent structure, which is commonly referred to as porphine, are the iron(III)complex of hemoglobin and the magnesium complex of chlorophyll. Both satisfy the Htickel and Sondheimer (4n + 2)- electron rule and thus form planar aromatic systems. 

Winslow RM. MP4, a new nonvasoactive polyethylene glycol-hemoglobin conjugate. Artif Organs 2004 28 800. 

Vandegriff KD, McCarthy M, Rohlfs RJ, et al. Colloid osmotic properties of modified hemoglobins chemically cross-linked versus polyethylene glycol surface-conjugated. Biophys Chem 1997 69 23. 

However, quantitative environmental exposure data for humans or other animals are often sadly lacking because studies are usually retrospective, and so, samples of body fluids will not have been taken. Bio markers of exposure are relatively transient and even conjugate with hemoglobin in blood, which are the most persistent, and are generally only detectable for... 

Hydroxyprimaquine (Fig. 7.46) will produce ROS in red cells, causing oxidative injury to the cytoskeleton and the oxidation of hemoglobin. The oxidized hemoglobin will bind via disulfide bridges to cytoskeletal proteins (seen as Heinz bodies under the microscope). This and other damages to the red cell lead to their removal by the spleen, and therefore anemia develops. 5-Hydroxyprimaquine also causes a depletion of GSH and the formation of GSS-protein conjugates. This metabolite is considerably more potent than 6-methoxy-8-hydroxylaminoquinoline. 

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