Modified hemoglobins

R. Benesch and R. E. Benesch, iu E. Antonini, L. R. Rossi-Bemardi, and E. Chiancone, eds.. Methods in En mology Hemoglobins, Academic Press, New York, 1981, pp. 147—158. Preparation and properties of hemoglobin modified with dedvatives of Pyridoxal. 

Bis(2-hydroxy ethyl) terephthalate (HET), polycondensation with bis(2-hydroxy-1- propyl) terephthalate (HDT), 7 634 Bis(3,5-dibromosalicyl)fumarate, hemoglobin modifier, 4 120... 

Bismuth tritelluride, 4 24 physical properties of, 4 20t Bismuth trithiocyanate, 4 25 Bismuth Vanadate Yellow, 19 405-406 pigment for plastics, 7 370t Bismuthyl carbonate hemihydrate, 4 25 Bismuthyl nitrate hemihydrate, 4 25 Bismuthyl nitrite hemihydrate, 4 25 Bis(lV-maleimidomethyl) ether (BME), hemoglobin modifier, 4 113 Bisoprolol fumarate, molecular formula and structure, 5 156t Bis(pentafluorophenyl)borane, 13 638 Bis(pentafluorophenyl)tri-4-tolylbismuth, 4 35... 

Nor-2-formylpyridoxal 5 -phosphate, hemoglobin modifier, 4 118-119 Noranda magnesium manufacturing process, 15 338... 

Baines AD, Ho P. O2 affinity of cross-linked hemoglobins modifies O2 metabolism in proximal tubules. J Appl Physiol 2003 95 563. 

Hirst, D.G. Wood, P.J. Chlorophenoxy acetic acid derivatives as hemoglobin modifiers and tumor radiosensitizers. 

In an interesting illustration of the first strategy, Sakaguchi and coworkers covalently attached hemoglobin to an aminopropyl silica particle and then polymerized organoalkoxysilanes on the surface of the hemoglobin-modified silica particle.85 The template was removed via treatment with oxalic acid.85 In more recent work, Zhang and coworkers utilized a similar approach. In their case, the sphere was made from the functionalized biopolymer, chitosan.86 The model template protein, bovine serum albumin, was covalently attached to the chitosan microsphere and then coated with a composite sol prepared from TEOS and an aminosilane.86... 

Figure 1 Revese phase HPLC analysis of hemoglobin modified by ascorbate and oxygen.

Figure 4. Typical saturation recovery signal for hemoglobin modified with N-ethylmaleimide spin label. The signal was obtained at 20°C in 50% aqueous glycerol with the experimental conditions indicated. Fp = pump power, P = observing power. (Unpublished data, by A. Kusumi, our laboratory.)...

Because the four nitrogens form an optimal cavity, porphyrins can bind a wide variety of metal ions to form metalloporphyrins (MP). Iron porphyrins are found in many biological systems and act as electron transfer mediators (cytochromes) or oxygen transfer agents (hemoglobin). Modified porphyrins are found in nature also in the form of chlorophylls and vitamin B,2 and related compounds. 

Preparation and Characterization of Monse Antibodies Against Hemoglobins Modified by Styrene Oxide... 

Figure 3. Competitive enzyme-linked immunosorbent assay. Immobilized antigen is styrene oxide-modified human hemoglobin (3.6 SO/Hb tetramer), competitors are human hemoglobins modified at different levels no modification (open circles), 0.15 SO/Hb tetramer (filled diamonds),...

A number of other colloids have also been used or proposed as potential expanders, but have not found clinical application because of various types of severe adverse reactions. One example is Alginon which is prepared by polymerization of sodium alginate (Tomoda and Inokuchi 1959). Further, the following colloids have been studied (Thompson 1960) methylcellulose, pectin, hemoglobin, modified human globin, isinglass, bovine serum albumin, polyvinyl alcohol, and starch. 

Fig. 1.3. Correlation between the Hill parameter and partial oxygen pressure at half saturation for chemically modified and mutant hemoglobins from Table 1. hemoglobins modified at a subunits o hemoglobins modified at P subunits. Curves represent calculated values obtained by varying the parameters a (curve a) and the parameter b (curve b), introduced as described in the text. Parameters used in the calculation are four parameters of the AE as given in Fig. 1.1, and five parameters of the GAE S = 0.6...

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