Hemoglobin A Conjugated Protein

Ferrohemoglobin, hemoglobin (reduced hemoglobin) a conjugated protein formed by combination of ferroheme and native protein. 

Hemoglobin (Hb) is a conjugated protein the pro.sthetic group heme (hematin) and the protein (globin). which is composed of four polypeptide chain.s. are usually in identical pairs. The total M, is about 66.000. including four heme molecules. The molecule has an axis of. symmetry and. therefore. is composed of identical halves with an overall ellipsoid shape of the dimensions SS X S5 X 70 A. 

Proteins may consist exclusively of a polymeric chain of amino acids these are the simple proteins. Quite often some other chemical component is covalendy bonded to the amino acid chain. Glycoproteins and Hpoproteins contain sugar and Hpid components, respectively. Porphyrins are frequently associated with proteins, eg, in hemoglobin. Proteins bound to other chemical components are called conjugated proteins. Most enzymes are conjugated proteins. 

A relatively simplistic concept of a protein structure is indicated m Fig. 1. The molecular weight for the hemoglobins is on the order of 68,000. They are conjugated proteins and consist of four heme groups and the... 

Some proteins also contain a non-peptide portion that is attached chemically to the polyamide chain. The non-peptide moieties are called prosthetic groups, and the proteins with such groups are called conjugated proteins. Examples are hemoglobin and myoglobin that crmsist of polypeptide portions with iron-porphyrin prosthetic groups attached. This particular prosthetic group, called heme, is illustrated in Fig. 8.2. There are also a number of proteins that are associated with a nucleic acid. They are known as nucleoproteins. 

II. Conjugated Proteins contain the protein molecule united with some other molecule in some manner other than as a salt, Nucleoproteins, glycoproteins, phosphoproteins, hemoglobins, etc., are typical members. 

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