Conceptus

Gupta RC, Thornburg JE, Stedman DB, et al. 1984. Effect of subchronic administration of methyl parathion on in vivo protein synthesis in pregnant rats and their conceptuses. Toxicol Appl Pharmacol 72 457-468. 

Embryotoxicity and Fetotoxicity—Any toxic effect on the conceptus as a result of prenatal exposure to a chemical the distinguishing feature between the two terms is the stage of development during which the insult occurs. The terms, as used here, include malformations and variations, altered growth, and in utero death. 

Gardner RL, Squire S, Zaina S, Hills S, Graham CF 1999 Insulin-like growth factor-2 regulation of conceptus composition effects of the trophectoderm and inner cell mass genotypes in the mouse. Biol Reprod 60 190-195... 

Single oral dose of 25, 50, or 100 mg/kg BW given to Ah-responsive pregnant mice on gestation day 11, 12, or 13 mice killed on day 18 of gestation Dose-dependent increase in embryo deaths, resorption of the conceptus, and frequency of developmental abnormalities (cleft palate, dilated kidney pelvis, thymus hypoplasia). ED50 for cleft palate was about 100 mg PCB 77/kg BW 10... 

B. Conception to implantation Reproductive functions in the adult female, preimplantation and implantation stages of the conceptus. Segment I Segment I Segment I Multigeneration One-generation developmental toxicity... 

The term zygote refers to the immediate result of fertilisation, i.e. one cell, whereas tiie embryo contains more than one cell. The term foetus refers specifically to mammalian development but has more of a legal meaning fiian a biological one. It is defined as file embryo from the end of the eighfii week after fertilisation. Nonetheless, the term is still used in biology and biochemistry and is used in this text to describe the developing embryo (also known as the conceptus). 

Hunter ES III, Tugman JA (1995) Inhibitors of glycolytic metabolism affect neumlation-stage mouse conceptuses in vitro. Teratology 52 317-323... 

Administered by inhalation to rats 6 hours/ day on days 7-16 of gestation, 12,000ppm trfetal toxicity in the form of reduced fetal weights overt maternal toxicity was also observed at this dose and was expressed as a significant reduction in weight gain and in feed consumption. Increased incidences of alopecia, lethargy, salivation, and ocular irritation were also observed in the treated dams, trans-1,2-Dichloroethylene was not considered to be uniquely toxic to the rat conceptus. 

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