Computer software data bases Systems

ELECTRAS - web-based data analysis system. The software supports 2x2 different modes of action the modes for expert and novice engineers and the modes for expert and novice computational chemists. htip //www2.chemie.uni-erlangen.de/projects/eDAS/index.himl... 

Because of these solutions, important technical data can be transferred from local instrumentation (control system) through data-based controllers to a control station with computers. The operator may use the many variations that the software data system provides. Technical data operation may be digital off/on messages such as the status of operation and the performance of alarms or analog measurements such as temperature, humidity, pressure, velocity, energy usage, etc. 

The minicomputer based system for Instrument automation at Glidden has been prevlousj.y reported (1). since that system predates the availability of low cost personal computers and data acquisition hardware, most of the hardware and software was designed and assembled in-house. ... 

Pure paper-based data collection systems are most suitable for small and short-term studies. Their advantages are that no computer hardware or software is needed at the participating sites because data are recorded manually on paper forms that are transferred to the centralized location in batches. A major drawback is that participating sites do not have real-time access to their data because no database is created locally. However, both hardware and software are needed at the centralized location for the data management system. The type of hardware and software used is determined by the configuration of the centralized computer. The most commonly used platforms include Open VMS, Unix, or PC, and one of the most widely used software packages is SAS [16]. 

The NIH/EPA CIS consists of a collection of chemical data bases together with a battery of computer programs for interactive searching through these disk-stored data bases. In addition the CIS has a data referral capability as well as a data analysis software system. It can be thought of then, as having four main areas ... 

Although not yet available, it is likely that Web-based performance testing systems will become available in the near future. Web-based systems will permit selected tasks to be presented on computers equipped with appropriate Web browser software. Hardware requirements include Internet access and appropriate memory and software to support Web-based applications. Depending on the design of the Web-based system, it is could be possible to tailor the specific tasks presented for the performance testing system from a menu of options. Alternatively, testing systems consisting of a standardized array of tasks can also be chosen. As such, the start-up costs of Web-based systems should be lower than with personal or handheld computer systems. Subject identification, date, and time can be recorded at the start of a test, and data from multiple subjects and test occasions can be stored in a central file for easy access to the data. 

Laboratory Information Management Systems (LIMS) are computer software-based integrators for laboratory reports generation. They gather all the information on a particular sample, including history, source, supplier addressing, data reports from all wet and analytical instruments, and conclusions and results drawn from this analysis. They receive information from a variety of inputs, in a variety of formats, and must have inputs for data confirmation and checking. 

The term computer system can define any of the following desktop systems client or of the following desktop systems client or server systems automated process control and laboratory systems host-based systems data acquisition and analysis systems and all associated software. The associated software comprises application software or firmware, system software, and computer system supporting documentation. ... 

Failure to validate computer software used as part of the quality system for its intended use according to an established protocol as required by 21 CFR 820.70(i). For example Software such as Excel, Access, and Word used to create and maintain data bases (rejects, complaints, and concessions) and electronic documents, is not validated. 

In silico models (or expert systems ) have also been developed. These are computer software-based structure-activity relationship and quantitative structure-activity relationship analyses of data libraries of acute toxicity data developed for use in evaluating and predicting the acute oral and inhalation toxicity potential of a chemical or drug. 

Abstract Validation of analytical methods of well-characterised systems, such as are found in the pharmaceutical industry, is based on a series of experimental procedures to establish selectivity, sensitivity, repeatability, reproducibility, linearity of calibration, detection limit and limit of determination, and robustness. It is argued that these headings become more difficult to apply as the complexity of the analysis increases. Analysis of environmental samples is given as an example. Modern methods of analysis that use arrays of sensors challenge validation. The output may be a classification rather than a concentration of analyte, it may have been established by imprecise methods such as the responses of human taste panels, and the state space of possible responses is too large to cover in any experimental-design procedure. Moreover the process of data analysis may be done by non-linear methods such as neural networks. Validation of systems that rely on computer software is well established. 

Advances in technology can facilitate the generation and transfer of patient documentation. As more pharmacies use the Internet as a means of communication, information can be transferred quickly and accurately over greater distances. Handheld computers and specialty software allow health care practitioners to document information in an electronic format that can be transformed immediately for rapid transfer to others. Reports in the literature have described methods to assess pharmacist interventions related to medication errors, the use of computer-based systems, and recently, the use of personal digital assistants (PDAs) in specific patient care areas. Many of these documentation systems tend to be individualized apphcations in which the transfer of data to other providers is not possible or quite limited. Often these systems focus on the generation of reports for workload analysis or accreditation purposes. 

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