Compounds identified from

Figure 4.10 Hit progression scheme for compounds identified from high-throughput screening. Note that the specific sequence of activities may vary from one organization to another, or even from one project to another, depending on practical considerations. For example, the location within the sequence of the chemical tractability filter may come before or after confirmation of reproducibility.

The first biologically active compounds identified from click beetles were hexanoic acid and pentanoic acid from Limonius canus and L. californicus, respectively [191]. 

Dickey et al. (403) reported a list of tau-reducing compounds identified from an initial in-cell Western screening assay. Drugs resulting in more than 25% reductions in tan levels with less than 10% reductions in GAPDH include aggregation inhibitors (diazaquone, methylene blue) antibiotics (alexidine HCl) antiproliferatives (colchicine, albendazole, chelidonine, rotenone) and steroids (norethindrone) (403). 

Table II. Secondary Compounds Identified from Parts of Tulip Tree (Liriodendron tulipifera L.)...

Thousands of bioactive compounds that have fascinating potentials to develop as nutraceuticals have been identified from marine sources. This chapter investigates the possibility of developing nutraceuticals from bioactive compounds, identified from marine sponges and symbiotic microorganisms. 

Table I. Compounds Identified from the Adsorption Spectra of jV,jV-Dimethylaniline in Zeolitesa...

Table I. Some Heterocyclic Compounds Identified from Thermal Interaction of 2,4-Decadienal and Cysteine...

Treatment 4i 155°C, 1 hour. Compounds identified from this treatment are similar to those from Treatment 3, as shown in Table I. All of the compounds were oxygenated products, namely ionone series compounds and some aliphatic aldehydes. 

Table VII. Volatile Compounds Identified from Roasting L-Theanine and D-Glucose...

K. (2005). Pheromonal activity of compounds identified from male Phyllotreta cruciferae field tests of racemic mixtures, pure enantiomers, and combinations with allyl isothiocyanate../. Chem. Ecol., 31, 2705-2720. 

Freier SM, Konings DAM, Wyatt JR, Ecker DJ, Mutational SURF A strategy for improving lead compounds identified from combinatorial libraries,... 

Table I Compounds Identified from Extracts of Pheromone Glands of North American Heliothis Species ...

Figure 14 Volatile compounds identified from headspace of infested corn leaves but not (or in trace amount) in uninfested leaves. UD undamaged leaves ADL artificially damaged leaves 1st/2nd, 3rd, 6th host instars infesting corn leaves. Reproduced from J. Takabayashi S. Takahashi M. Dicke M. A. Posthumus, J. Chem. Ecol. 1995, 21, 273-287.

Figure 6.14. Compounds identified from the ACD database through superstructure search.

Figure 6.15. Compounds identified from the ACD database through similarity search using 60% similarity as threshold. The lower the specified similarity the higher the number of hits identified.

The reported stimulation of fungal spore germination by volatile compounds identified from plant sources (8) and the... 

Recent advances in robotics, cheminformatics, and assay formats, including miniaturization, have made the generation of small-molecule hits by high-throughput screening (HTS) campaigns a more or less routine procedure in the pharmaceutical and increasingly the academic sectors see also Chapters 1 and 2). Active compounds identified from HTS are then validated in confirmatory assays and their respective activities characterized in more detail... 

Binary encoding technology [71-73] has been used to identify selective CAII inhibitors from two libraries (6,727 members and 1,143 members) [419, 420]. The first library was composed of acyclic and cyclic amino acids and the second library was composed of dihydrobenzopyrans. The arylsul-phonamide moiety, a known pharmacophore for CAII inhibition, was included in order to bias the library. The active compounds identified from the first library exhibited a preference for lipophilic groups at R2 (library 35 Kd 4 nM) [419]. Again active members from the 1143 dihydrobenzopy-ran compound library were 4-carboxybenzene sulphonamide derivatives (library 36 Kd 15 nM) [420],... 

The analysis of the active ingredients of these herbal "cures" has supplied an enormous number of the medicines that have been used in the last 100 years. It has been estimated that 119 compounds identified from 90 plants have been used as single entity medicinal agents (10). Significantly, the vast majority cf these drugs were obtained as a result of examiningthe plant based on itsethnomedical use (6,7, 9,11). 

McLeod G. and Ames J. (1986) 2-Methyl-3-(methylthio)furan a meaty character impact aroma compound identified from cooked beef. Chem. Ind. (London) 175-7. 

Over the last seventy years, several review articles on the constituents of tobacco and tobacco smoke have been published. In 1936 Bruckner (451) discussed the biochemistry of tobacco. In his book, he briefly mentioned that tobacco contained chloride. Kosak (2170) in 1954 categorized about fifty components in tobacco smoke whose identities were certain. Under his heading of Inorganic Components KOSAK listed Chlorides ( ). The question mark indicated that Kosak did not consider the evidence in the literature to be definitive proof of the identity of the component. Latimer (2270) in 1955 listed 231 compounds identified from tobacco and tobacco smoke. At that time, methyl chloride was the only halogenated compound identified in tobacco smoke. Johnstone and Plimmer in 1959 (1971) listed 950 compounds in tobacco and tobacco smoke. In their review, they listed only one halogenated compound as identified in tobacco, 1,1,-dichloro-2-2(4,4 -dichlorodiphenyl)ethane (TDE or DDD) and two in tobacco smoke, methyl chloride (specifically) and certain other unnamed volatile chlorides. Bentley and Berry in 1959 and 1960 (282, 283), and Berry (296) in 1963 failed to report any halogenated compounds in tobacco or tobacco smoke. Izawa (1900) in 1961 reported 440 identified compounds in tobacco and tobacco smoke. In his report he listed only methyl chloride as being identified in tobacco smoke. 

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