Compositae treatment

A different cychzation reaction of 460, by treatment with iodine and silver oxide, gave l,6-dioxaspiro[3.4]octanes 469 (Scheme 130). This heterocychc core present in a series of sesquiterpenic lactones has interesting biological activity and is isolated as secondary metabolites from species of the Compositae family . 

Analysis of Tagetes minuta. L. (Compositae) revealed the presence of cis- (40a) and trans- (40b) -ocimenones (= tagetenones), in addition to the previously known tagetones and dihydrotagetones. The new compounds were synthesized by treatment of a mixture of 3-methylbut-2-enoyl chloride and isoprene with a Lewis acid, e.g. SbClg. ... 

Asteraceae(Compositae) Artemisia afra Willd. (African wormweed) Fifi (Shambaa), Ushemeli (Sukuma) A,L Heated aerial parts are fermented and used to treat sore throats and fever in children. Aerial parts are taken by adults for treating indigestion. A decoction of boiled roots is taken two to three times daily for treatment of intestinal worms. For emetic action, the leaves are chewed and the juice swallowed (35)... 

The aerial parts of Eupatorium articulatum L. (Compositae) are widely used in the Andes region of Ecuador for the treatment of inflammatory diseases. The methanolic extract of this species exhibited a significant in vivo anti-inflammatory activity, when tested for its ability to reduce carrageenan-induced inflammation in rat paw oedema, thus supporting the traditional use claimed for this plant. Since the inflammation process is associated to the generation of reactive oxygen species and the induction of lipid peroxidation, the antioxidant properties of the extract were also studied [45]. Significant activity was observed when tested for its ability... 

Actions and TTses.—Internally —Irritant and corrosive poison. Externally. —Either alone or mixed with four parts of Tinctura MyrrhsB composita, it is employed as a caustic in the treatment of fistulas, thrushes, canker, luxuriant granulations, foul, and foot-rot. It occasions but little pain. 

All the principal alkaloids of both groups possess as a common structural feature the 4-methoxyquinoline unit, in consequence of which they undergo a typical isomerization to iV-methyl-4-quinolones on vigorous treatment with methyl iodide. This reaction, which has been of considerable assistance in the elucidation of the structures of the alkaloids, also provides a chemical relationship with the alkaloid of Eehinopa species (Compositae), which was shown to be W-methyl-4-quinolone itself. The isomeric lV-methyl-2-quinolone occurs in Angostura bark. 

Farkas J (1981) Perioral dermatitis from marjoram, bay leaf and cinnamon. Contact Dermatitis 7 121 Stampf J, Castagnoli N, Epstein W, et al. (1990) Suppression of urushiol-induced delayed-type hypersensitivity responses in mice with serum IgG immunoglobulin from human hyposensitized donors. J Invest Dermatol 95 363-365 Baadsgaard O (1986) Circulating and in situ lymphocyte subsets and Langerhans cells in patients with Compositae oleoresin dermatitis and increased ultraviolet A sensitivity during treatment with azathioprine. J Am Acad Dermatol 14 577-581... 

Inula, from Compositae, has more than 100 species in the world, mainly found in Europe, Africa and Asia. There are more than 20 species in China. Inula britannica is a wild plant found in Eastern Asia, including China, Korea, and Japan. In traditional Chinese medicine. Inula britannica and Inula japonica are called Xuanfiihua and the flowers have been used for the treatment of digestive disorders, bronchitis and inflammation. Its extracts are reported to have anti-inflammatory, anti-bacteria, anti-hepatitis and anti-tumorigenic activities ) ... 

Kozmin et al. applied enyne metathesis between olefin and silyl ynolate to the synthesis of two isomeric eremo-philanes (190 and 191, Scheme 24.48) isolated from the flowering plants of the Compositae family. RCM of 186 was carried out in the presence of [Ru]-II, and the subsequent treatment with HF gave enone 188. 

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