Comparative methodology

Extensive studies on the effect of substrate concentration and on the bioavailability of the substrate to the appropriate microorganisms have employed samples of natural lake water supplemented with suitable nutrients. There are few additional details that need to be added since the experimental methods are straightforward and present no particular difficulties. Considerable use has also been made of a comparable methodology to determine the fate of agrochemicals in the terrestrial environment. 

Bankfalvi A, Boecker W, Reiner A. Comparison of automated and manual determination of HER2 status in breast cancer for diagnostic use a comparative methodological study using the Ventana BenchMark automated staining system and manual tests. Int. J. Oncol. 2004 25 929-935. 

Mendelsohn ML. Absorption cytophotometry comparative methodology for heterogeneous objects, and the two-wavelength method, in Introduction to Quantitative Cytochemistry (Wied GL, ed.), Academic Press, New York, 1966, pp. 201-214. 

Comparability Methodology error Field and laboratory procedure error... 

Burns, J.J., and F.H. Fay (1970). Comparative methodology of the skull of the Ribbon seal, Histriophoca fasciata, with remarks on the sys-tematics of Phocidae. J. Zool. (Lond.) 161 363— 394. 

In addition to the choice of relative orientation, conformational flexibility may prove to be more of a problem in future applications than for the systems described here. This is particularly likely when the molecules are very similar. Of course, it is not hard to anticipate situations for which a p-space approach is unlikely to be useful. Obvious examples are those in which the observed activity is largely dependent on the values of bulk physical properties or on well-defined steric effects. We have stressed previously [12] that no single approach to molecular similarity can be expected to be a universal panacea. For example, any comparative methodology, such as that presented here, can only very indirectly provide information concerning interactions with biological receptors. 

Using the comparative methodology discussed above, we will in the following present some results based on data which were collected with the help of national experts in each of the EU member States as well as in Norway, Switzerland and the Czech Republic. The financial performance of the farms is assessed using the indicators profits per ha and profits per family work unit in combination with important factors which determine profitability, e.g. yield levels and prices realised and support payments received. Most of the studies analysed are based on approach 3. In some cases, the selection of an adequate reference group was, in our opinion, not completely successfixl. Since the selection of the reference system has a large influence on results, the findings of the respective studies have to be interpreted with due care. 

Comparable methodologies include the SCORE methodology by the Supply Chain Council (Morrow et al. 2009), which has now been extended to include risk assessment. It is however notable that this method uses benchmarking, not simulation for assessment. 

It was therefore decided to develop a comparative methodology which would circumvent the limitations of other rapid comparative methods and which would enable data aggregation from several studies. Ideally, this method should not require the presentation of an excessive number of samples in each new analysis, which would amount to running the evaluation on the full product set again. Besides, this methodology should be possibly performed by subjects without special training, as in free sorting. 

Urbansky, E.T. and Bashe, W.J., Comparative methodology in the determination of a-oxocarboxylates in aqueous solution ion chromatography vs. gas chromtography after oximation, extractions and esterification, /. Chromatogr. A, 867, 143, 2000. 

At the system level, for each hazard, a qualitative/comparative methodology suggested earlier (please see section Complex Railway Project Safety Management - Manchester South Capacity Improvement Project ) should be applied. 

Chedier, L.M. et al. Comparative methodology for isolation of flavonoid glycosides from Clusia criuva Cambess, J. High Resol. Chromatogr., 22, 527, 1999. 

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