Color sorbitol

An oral dental riase geaeraHy coasists of water, alcohol, a humectant, an emulsifier, flavor, color, and an active agent. Water is the primary vehicle. The alcohol provides bite and is also a formulation aid. The humectant improves the feel ia the mouth and also prevents locking of the cap to the container between uses glycerin or noncrystaUiziag sorbitol may be satisfactory. The emulsifier is a nonionic type, for example, a polyoxyethylene—polyoxypropylene block copolymer or a polyoxyethylene sorbitan fatty acid ester. Flavors are generally a type of mint or cinnamon. Colors are FD C or D C. 

The sugar alcohols sorbitol (hR, 15 — 20), mannitol (hRf 20—25) and xylitol hRf 30 — 35) appeared as light to dark brown chromatogram zones on a beige-colored background. The detection limits were 1 ng substance per chromatogram zone. 

Sorbitan esters of fatty acids are well known. Similar products can be made from ether carboxylic acids and sorbitol without an acid catalyst with a good color [39]. The advantage of these products is that the hydrophilicity can be adjusted by the polyethylene glycol content in the ether carboxylic acid. 

Other workers have used the tristimulus parameters to study the kinetics of decomposition reactions. The fading of tablet colorants was shown to follow first-order reaction kinetics, with the source of the illumination energy apparently not affecting the kinetics [49]. The effect of excipients on the discoloration of ascorbic acid in tablet formulations has also been followed through determination of color changes [50]. In this latter work, it was established that lactose and Emdex influenced color changes less than did sorbitol. 

A simple relationship was not found between shrinkage and glass - rubber transitions of both peach and apricot tissue (Campolongo, 2002 Riva et al., 2001, 2002). Even when sorbitol use increased AT (= T — 7g ) values, both the color and the structure showed the highest stability. The fact that sorbitol performed better than sucrose indicates that the chemical nature of the infused solute is more important than its glass transition temperature in preventing structural collapse, in accordance with the results reported by del Valle et al. (1998). 

Parabens are approved for use in oral solution and suspensions at a concentration of 0.015% to 0.2% w/v. Due to their low solubility, the sodium salts of parabens are often used in aqueous formulations. The parabens are most effective in the pH range of 2 to 6, and their antimicrobial activity decreases with increasing pH. Additionally, they are very unstable at pH 8 or above in solution. Methyl paraben has also demonstrated incompatibility with sorbitol and may show some discoloration in the presence of iron. The absorption of methylparaben by plastics has been reported with the amount absorbed being dependent upon the type of plastic and vehicle. However, no absorption has been reported for low density polyethylene (LDPE) or high density polyethylene (HDPE) containers. Certain coloring agents such as yellow iron oxide, ultramarine blue, and aluminum silicate can extensively absorb ethyl paraben in simple aqueous systems, thus reducing its preservative efficacy. 

Additionally, the stability of dyes in solution can be dependent upon the specific excipients used in the formulation. For example, FD C Blue 2 was found to fade more rapidly in the presence of several sugars (sorbitol, mannitol, dextrose, sucrose, and lactose) and that the nonionic surfactant Pluronic F-68 promoted the fading of FD C Blue 2. The combination of coloring agents can lead to complications... 

Alka-Scltzer Pigs Various analgczics and decongestants X X Artificial Colors X Sorbitol ... 

Surimi is fish paste from deboned fish used to make simulated crab legs and other seafood. For preservation the paste is blended with cryoprotectants, such as sucrose, sorbitol and phosphates, and frozen. To make the final product, the frozen paste is thawed, blended with starch and extruded as a film onto a belt. The belt takes the film into an oven that heat-denatures the fish protein and cooks the starch. The film is then rolled to form striations, shaped, colored and cut. Depending on the required distribution, the product is frozen or refrigerated. Potato and tapioca starch were used in surimi products 400 years ago, since they provided a cohesive, elastic matrix consistent with seafood. Frozen distribution has made the use of highly-stabilized, moderately crosslinked tapioca starch popular, alone or with native tapioca starch. Modified waxy maize products are used, as is unmodified com starch, for increased cuttability. Kim188 reported that the gel strengthening ability of starch correlates with starch paste viscosity. 

Although those acetals and ketals under consideration have not so far been employed extensively in industry, their industrial potentialities have not been overlooked, as the following four examples show. A color test based on tri-(o-chlorobenzylidene)-sorbitol has been used to detect the... 

Polysorbate 20 occurs as a yellow- to amber-colored liquid. It is a mixture of laurate partial esters of sorbitol and sorbitol... 

Polysorbate 60 occurs as a yellow to orange colored, oily liquid or semigel. It is a mixture of stearate and palmitate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 moles of ethylene oxide (C2H40) for each mole of sorbitol and its mono- and dianhydrides. It is soluble in water, in aniline, in ethyl acetate, and in toluene, but it is insoluble in mineral oil and in vegetable oils. 

Urine can turn dark in color in the first 24 hours after parenteral iron injection. The reddish-brown color, which has been observed after the intramuscular injection of iron sorbitol-citric acid complex (SED-8, 515), is due to urinary excretion of part of the iron compound. It has to be distinguished from the black discoloration that may develop if urine of patients who have received iron-sorbitex is allowed to stand, assumed to be due to production of iron sulfide by bacterial growth. Phenomena of this kind are unhkely to occur after the... 

A pediatric formulation of lincomycin - 2 - phosphate at pH 7.5 containing sucrose, sorbitol, glycerin, alcohol, saccharin, preservatives, flavor and color yielded hydrolysis rate constants in reasonable agreement with those predicted from the simple aqueous buffer kinetic data (19). 

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