Color label requirements

Part 70 Color additives — This part includes a definition of a color additive, restrictions on use of color additives, packaging and labeling requirements, and safety evaluation of color additives. 

Part 73 Listing of color additives exempt from certification — This part identifies listed color additives exempt from certification, provides chemical specifications for these color additives, and identifies uses, restrictions, labeling requirements, and requirements for certification. 

The numbers of each type of label required Label material type (e g., Traffolyte, stainless steel) Label colors (e.g., Traffolyte sandwich colors)... 

In the USA, specific labeling requirements are in place for prescription drugs that contain tartrazine (see Section 18) as this color was found to be the potential cause of hives in fewer... 

Code of Federal Regulations. 21 CFR. Ch. 1 (4-1-92 Edition). Subpart B - Specific Food Labeling Requirements. 101.22 Foods Labeling of Spices, Flavorings, Colorings and Chemical Preservatives (1992)... 

Colorants, other than titanium dioxide, are rarely used in plastic containers however, the use of colorants is required for the cap. The American Academy of Ophthalmology (AAO) recommended to the FDA that a uniform color coding system be established for the caps and labels of all topical ocular medications. Industry new drug applicants are required to either follow this system or provide an adequate justification for any deviations from the system. The AAO color codes, as revised and approved by the AAO Board of Trustees in June 1996, are shown in Table 4. The FDA and AAO have extended the cap color scheme to differentiate different classes of newer Rx drugs for the benefit of the patient who may be using more than one product. The intent is to help prevent errors in medication and improve patient compliance. It is important for the pharmacist to explain this color coding to the patient and/or caregiver since it can be defeated if the cap is not returned to the proper container after each use. 

Placing a label on a package that does not meet color specification requirements (depending on the variance). 172.407(d) 1,000. 

An explanation of the signs and labels and/or color coding required by the standard. 

An explanation of the procedures to follow if an exposure incident occurs, including the method of reporting the incident and the medical follow-up that will be made available Information on the postexposure evaluation and follow-up that the employer is required to provide for the employee following an exposure incident An explanation of the signs and labels or color coding required... 

Explain the use and limitations of safe woik practices, engineering controls, and PPE. Explain the use of label, signs, and color coding required by the standard. 

A color-coded DOT 4-inch diamondshaped label must be applied to the container to satisfy the labeling requirements set forth in 49 CFR Part 172 Subpart E. [1]... 

The reversibility of the conventional Diels-Alder reaction makes it a prime candidate for the synthesis of smart materials that exhibit a temperature-dependent transition between two physical properties (such as viscosity or color). However, many applications (such as biological labeling) require irreversible conjugation chemistry that also is very fast under mild and dilute reaction conditions. Eor such purposes, the inverse electron-demand Diels-Alder (IVED-DA) reaction between electron-deficient tetrazine derivatives and various alkenes is incredibly efficient. 

The acid may be shipped in tank cars, tank tmcks, iso-tainers or dmms via common carrier (40). The shipping ha2ard class is Corrosive Material, the DOT labels and placards required are Corrosive and Poison. The UN number is 1754. When iron content and color are not of concern, the acid may be stored and shipped in steel equipment. The iron content is generally 25—50 ppm and the color is pale yellow to amber. 

Most importantly, a clear differentiation between color preparations derived from natural sources requiring E number declarations (i.e., E 162 for beet red) and coloring foodstuffs derived from typical food commodities should be made (Figure 2.4.2). For the latter, only physical unselective extraction based on oil or water followed by concentration through heating is allowed, following the recent trend for clean-labelled food. ... 

During fermentation, the betacyanins turned out to be more stable than the betaxanthins, which is assumed to be due to their thermal stability rather than different tendencies of pigments toward microbial degradation. Besides these biological tools, beet extracts may also be purified by column chromatographic techniques. After removal of sugars, salts, and phenolics, the nature-derived color preparation will, however, require E number labeling. ... 

Data concerning use patterns of food additives and color additives are difficult to obtain. Although additives must be included on product labels in descending order of inclusion, major effort is required to evaluate even a simple presence on this basis, which would provide at best only limited information on the amounts used. In most cases, quantitative analytical controls are limited to efforts by control authorities to determine compliance with legal limits. Levels below these limits are of limited interest and are usually not published. ... 

Since food colorants are used as food additives, they must also comply with legislative requirements. Food legislation in the European Union (EU) and the United States (US) differs with regard to additives and labeling. Therefore, this section provides an overview of legislation in the EU (Section 7.1.6.1) and the US (Section 7.1.6.2) and discusses colorants permitted for use in food products according to the different requirements. 

Additional regulations that provide specific requirements for color additives in foods are found in other parts of the CFR. Labeling of food products is found at 21 CFR 101.22(k). Color additives are sometimes called artificial colors or artificial colorings [21 CFR 101.22(a) (4)]. From a regulatory standpoint, a colorant is a dye or pigment used in a food contact material such as a polymer that does not migrate to food. Such materials are regulated as food additives [21 CFR 178.3297(a)], not as color additives. ... 

---