Colon-Specific Drug Delivery System

Ishibashi, T., Pitcairn, G.R., Yoshino, Ft., Mizobe, M., and Wilding, I.R., Scintigraphic evaluation of a new capsule-type colon specific drug delivery system in healthy volunteers, J. Pharm. Sci., 87 531-535 (1988). 

Aiedeh, K., and Taha, M.O., Synthesis of chitosan succinate and chitosan phthalate and their evaluation as suggested matrices in orall administered, colon-specific drug delivery systems, Arch. Pharm (Weinheim), 332 103-107 (1999). 

Chiu, H.C., Hsiue, G.H., Lee, Y.P., and Huang, L.W., Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system, J. Biomater. Sci. Polym. ed., 10 591-608 (1999). 

A Practical Approach in the Design of Colon-specific Drug Delivery Systems... 

Recently L. Hovgaard and H. Brpndsted published a critical review in which they stated that polysaccharides appear as promising compounds for use in developing colon-specific drug delivery systems [66],... 

Among newly developed colon-specific drug delivery systems, pressure-controlled delivery capsules (PCDCs) [161] can be mentioned. Their mechanism of action is based on the relatively strong peristaltic waves taking place in the colon and leading to an increased luminal pressure. They consist of a capsular-shaped suppositories coated with a water-insoluble polymer (ethyl cellulose). Once taken orally, PCDCs behave like an ethyl cellulose balloon, because the suppository base liquefies at body temperature. In the upper GI tract, PCDCs are not directly subjected to the luminal pressures since sufficient fluid is present in the stomach and small intestine. The reabsorption of water in the colon provokes an increase of the luminal content viscosity. As a result, increased intestinal pressures directly affect the system via colonic peristalsis. Consequently, PCDCs mpture and drug release in the colon take place. 

Friend, D.R. Chang, G.W. A colon specific drug delivery system based on drug glycosides and glycosidases of colonic bacteria. J. Med. Chem. 1984, 27, 261-266. 

Van den Mooter, G. Samyn, C. Kinget, R. In vivo evaluation of a colon-specific drug delivery system an absorption study of theophylline from capsules coated with azo polymers in rats. Pharm. Res. 1995,12, 244—247. 

Inulin has many potential uses in pharmaceutical applications, as a filler-binder in tablet formulations to stabilize therapeutic proteins or to enhance the dissolution of lipophilic drugs.Methacrylated inulin hydrogels have been investigated for the development of colon-specific drug delivery systems. ... 

Patel AU, Shah T, Amin A. Therapeutic opportunities in colon-specific drug-delivery systems. Crit Rev Ther Drug Carrier Syst 2007 24 147-202. 

Reddy SM, Sinha VR, Reddy DS Novel oral colon-specific drug delivery systems for pharmacotherapy of peptide and nonpeptide dmgs, Dmgs Today 1999, 35, 537-580. 

Membranes play a fundamental role also in the colon-specific drug delivery systems. This administration route, whose advantages have been well recognized and documented [158], provides more effective therapy of colon-related diseases such as irritable bowel syndrome and inflammatory bowel disease (IBD) including Crohn s disease and ulcerative colitis. 

Uses Thickener, stabilizer in foods biological additive in cosmetics film-former, moisturizer for hair and skin styling preps. capsule used as colon specific drug delivery system absorbs heavy metals from water and industrial waste streams coagulant, filter aid for potable water as dyeing assistant in photographic emulsions plant protectant dietary fiber biomedical applies. bacteriostat preservative stabilizer binder for fats, protein, metals medical aids (artificial skin, plasters, bandages) odor absorbent for cat litter Features Natural lipophilic may absorb fat-sol. vitamins... 

---