Chitosan phthalate

Aiedeh, K., and Taha, M.O., Synthesis of chitosan succinate and chitosan phthalate and their evaluation as suggested matrices in orall administered, colon-specific drug delivery systems, Arch. Pharm (Weinheim), 332 103-107 (1999). 

Birhk, E., Buyuktriyaki, S., Ersoz, A., DenizU, A., and Say, R. 2006. Selective separation of thorium using ion imprinted chitosan-phthalate particles via solid phase extraction. Sep. Sci. Technol. 41 3109-3121. 

Nontoxic and noncorrosive solvent systems can be used when chitosan is considered instead of chitin for the manufacture of fibers. Improvements of the fiber quality rely mostly on technical shrewdness for instance the use of potassium hydrogen phthalate at pH 4-5 imparted better mechanical properties [255]. 

Y. Liu, T. He, C. Gao, Surface modification of poly(ethylene tere-phthalate) via hydrolysis and layer-by-layer assembly of chitosan and chondroitin sulfate to construct cytocompatible layer for human endothelial cells. Colloids Surf. B Biointerfaces 46 (2) (2005) 117-126. 

Aiedeh KM, Taha MO. Synthesis of chitosan triethylene glycol phthalate and its evaluation as a binder in wet granulation procedures. Die Pharmazie 1999 54 614—619. Vromans H, Poels-Janssen HGM, Egermann H. Effect of high shear granulation on granulate homogeneity. Pharm Dev Technol 1999 4 297 303. 

Another advantage is that natural polymers can be modified using suitable reagents to obtain semisynthetic polymers. Modified starch/dextran, cyclodextrins, cellulose, alginate, scleroglucan and chitosan derivatives are the most important semisynthetic polymers for the drug industry [17-19]. In this respect, starting from the natural cellulose, at least 10 semisynthetic derivatives are widely used for the optimization of pharmaceutical formulations cellulose acetate (CA), cellulose acetate butyrate (CAB), cellulose acetate phthalate (CAP), methylcellulose (MC), ethylcellulose (EC), hydroxy-ethyl cellulose (HEC), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), carboxymethylcellulose (CMC), nitrocellulose [16,20,21]. 

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