Colon carcinogenesis synthase

Rao, C.V., Cooma, I., Simi, B., Maiming, P.T., Connor, J.R. and Reddy, B.S., Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res., 62, 165, 2002. 

Much evidence suggests that chronic inflammation is closely related to colon carcinogenesis. Thus, factors involved in chronic inflammation are of great interest as targets of cancer chemopreventive agents. Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are abxmdantly expressed in the epithelium of colitis and colon cancer cells and appear to play an important role in colon carcinogenesis (J-4),... 

Rao, C.N., et al., Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase selective inhibitor. Carcinogenesis, 20, 641, 1999. 

Tanaka, T., Suzuki, R., Kohno, H., Sugie, S., Takahashi, M., and Wakabayashi, K. (2005) Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase. Carcinogenesis 26, 229-238. 

Ambs, S., Hussain, S.P., and Harris, C.C. (1997). Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J. 11,443-448. Ambs, S., Merriam, W.G., Bennett, W.P., Felley-Bosco, E., Ogunfusika, M.O., Oser, S.M., Klein, S., Shields, P.G., Billiar, T.R., and Harris, C.C. (1998). Frequent nitric oxide synthase-2 expression in human colon adenomas implication for tumor angiogenesis and colon cancer progression. Cancer Res. 58, 334—341. 

Chhatwal, V.J., Ngoi, S.S., Chan, S.T., Chia, Y.W., and Moochhala, S.M. (1994). Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa. Carcinogenesis 15,2081-2085. 

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