Collagen in cartilage

A short-chain collagen, found in hypertrophic mineralizing cartilage, with a similar structure to ts pe VIII collagen Forms fibrils that are associated with ts pe II collagen in cartilage and intervertebral disc... 

Hyaluronic acid and collagen are the two main structural components. The collagen is similar to that found in cartilage, consisting of three alpha-chains and known as type II collagen, although subtle differences are now recognized (Swann and Constable, 1972 Swann, 1980). 

Hollander AP et al (1996) Enhanced denaturation of the alpha (II) chains of type-II collagen in normal adult human intervertebral discs compared with femoral articular cartilage. J Orthop Res 14(l) 61-66... 

Cell metabolism induction. Methanol extract of STE, in collagen-producing cells, stimulated glycolysis by 80% in cartilage but was not affected in the other tissues. Medium alkaline phosphatase activity was unaffected. In the frontal bone and cartilage, [ H]hydroxyproline and [ H]proline contents were decreased. Neither was affected in the aorta. 

Type I, II, and III collagens are fibrillar, and are found in tendon, skin, bone, cornea, carti lage, vitreous body, and blood vessels. Types IX and XII are fibril-associated, and are found in cartilage, tendon, and ligaments. Type IV and VII form networks in basement membrane and beneath stratified squamous epithelia. 

Copper is an essential component of numerous key metalloenzymes which are critical in melanin formation, myelin formation and crosslinking of collagen and elastin. Copper plays a vital role in hemopoiesis, maintenance of vascular and skeletal integrity, and structure and function of the nervous system. Thus a deficiency of copper can lead to a variety of adverse effects such as increased fragility in bones, aneurysm formation in arteries and a loss of lysyl oxidase activity in cartilage.54 57 Articles on copper also appear in Siget1, volumes 3 and 5, all of volumes 12 and 13, and volume 14,... 

Hedlund, H., Hedbom, E., Heinegard, D., Mengarelli-Widholm, S., Reinholt, F. P., and Svensson, O. (1999). Association of the aggrecan keratan sulfate-rich region with collagen in bovine articular cartilage./. Biol. Chem. 274, 5777-5781. 

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