Cockroaches effects

Methoprene and hydroprene are first-generation juvenoids that iacorporate minor stmctural optimisation of neotenin to increase persistence. Methoprene, 1-isopropyl (E,E)-ll-methoxy-3,7,ll-tnmethyl dodecadi-2,4-enoate (129) (bp 100 C/6.7 Pa, vp 3.5 mPa at 25°C), is soluble ia water to 1.4 mg/L. The rat oral LD q is >34,000 mg/kg. Methoprene has been used as a mosquito larvicide, ia baits for ant control, and as a catde feed-through treatment for horn fly control. Hydroprene, methyl (H,H)-3,7,ll-trimethyl-dodecadi-2,4-enoate (130) (bp 174°C at 2.5 kPa, vp 2.5 mPa at 25°C), is soluble ia water to 0.54 mg/L. The rat oral LD q is >34,000 mg/kg. Hydroprene is especially effective against aphids and cockroaches. 

Encapsulated dia2innon sold as Knox-Out 2FM is a commercial encapsulated pesticide formulation said to have reduced dermal and oral toxicity as well as prolonged effectiveness. The capsules, prepared by interfacial polymeri2ation, are claimed to be highly effective against cockroaches with no objectionable odor and low insect repeUence. The capsules are beheved to function as a contact poison when insects walk on it and as a stomach poison when insects preen capsules stuck to their legs and ingest them (71). 

In one example (Lawrence and Casida 1984, Abalis et al. 1985) rat brain microsacs were used to test the action of cyclodiene insecticides such as dieldrin and endrin on the GABA receptors contained therein. The influx of radiolabeled CL into the microsacs via the pore channel of the receptor was inhibited by these chemicals. A similar assay was developed using microsacs from cockroach nerve. Assays with this preparation showed again the inhibitory effect of a cyclodiene (this time heptachlor epoxide) on CL influx. Also, that microsacs from cyclodiene resistant cockroaches were insensitive to the inhibitory effect of picrotoxinin, which binds to the same site on the GABA receptor (Kadous et al. 1983). 

Thomas MS, Kunkel SL, Lukacs NW. Differential role of IFN-gamma-inducible protein lOkDa in a cockroach antigen-induced model of allergic airway hyperreactivity systemic versus local effects. J Immunol 2002 169(12) 7045-7053. 

Tsuji, H. and Y. Taneike. 1988. Insecticidal effect of diflubenzuron against cockroaches. Japan. Jour. Sanitary Zool. 39 19-25. 

Gammon, D.W., L.J. Lawrence, and J.E. Casida. 1982. Pyrethroid toxicology protective effects of diazepam and phenobarbital in the mouse and the cockroach. Toxicol. Appl. Pharmacol. 66 290-296. 

Cross-resistance to pyrethroids for outdoor use has developed markedly in M. domestica, mosquitoes, cockroaches, and so on however, it has also been found that natural pyrethrins as well as d-allethrin and prallethrin (ETOC ), which have very similar chemical structures and the same configuration as natural pyrethrins, show an extremely low degree of cross-resistance development by these highly-resis-tant sanitary pests compared to photostable pyrethroids. Many novel synthetic pyrethroids recently developed as household insecticides have tended to pursue efficacy improvements in terms of rapid knock-down effects, residual efficacy or volatility. 

It can also be made by nitrating diethyl phenyl phosphate below 0°. It is a red oil, almost insoluble in water, and Schrader found it effective against aphids, while Ball and Allen1 proved it active against the housefly, milkweed bug and cockroach. Later work showed it active against the two-spotted spider mite. 

Pesticides are used to kill household insets, rats, cockroaches, and other pests. Pesticides can be classified based on their chemical nature or use as organophosphates, carbonates, chlorinated hydrocarbons, bipyridyls, coumarins and indandiones, rodenticides, fungicides, herbicides, fumigants, and miscellaneous insecticides. The common adverse effects are irritation of the skin, eyes, and upper respiratory tract. Prolonged exposure to some chemicals may cause damage to the central nervous system and kidneys [32,33]. 

TABLE 4.3 Effects of Various Statins on Ootheca and Larval Development in German Cockroach... 

Zapata R., D. Martin, M-D. Kulachs, and X. Belles (2002). Effects of h3fpocholesterolaemic agents on the expression and activity of 3-hydroxy-3-methylglutaryl-CoA reductase in the fat body of the German Cockroach. Archives of Insect Biochemistry and Physiology 49 177-186. 

Zapata R., M-D. Piulachs, and X. Belles (2(X)3). Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase lower fecundity in the German cockroach Correlation between the effects on fecundity in vivo with the inhibition of enzymatic activity in embryo cells. Pest Management Science 59 1111-1117. 

Relatively high concentrations of boron componnds are used to control fruitflies, cockroaches, gypsy moth larvae, houseflies, and woodboring insects (Sprague 1972 USEPA 1975 Table 29.6). Boric acid is an effective stomach poison for several insect species, including German cockroaches (Blattella germanica), that are unable to detect the presence of boric acid (USEPA 1975). Insect infestation of wood and other substrates can be prevented by pretreatment with boric acid or borax at... 

Boric acid, 99% powder Effective for control of household cockroaches, ants, and fleas 2... 

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