Allergic airway hyperreactivity

Thomas MS, Kunkel SL, Lukacs NW. Regulation of cockroach antigen-induced allergic airway hyperreactivity by the CXCR3 ligand CXCL9. J Immunol 2004 173(l) 615-623. 

Nieuwenhuizen, N., Lopata, A.L., Jeebhay, M.L.F., Herbert, D.R., Robins, T.G., Brombacher, F. 2006. Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis. Journal of Allergy and Clinical Immunology 117(5) 1098-1105. 

Dabbagh K, Xiao Y, Smith C et al. Local blockade of allergic airway hyperreactivity and inflammation by the poxvirus-derived pan-CC-chemokine inhibitor vCCI. J Immunol 2000 165 3418-3422. 

Dabbagh, K., Xiao, Y., Smith, C., Stepick-Biek, P., Kim, S.G., Lamm, W.J., Liggitt, D.H., and Lewis, D.B. (2000) Local blockade of allergic airway hyperreactivity and inflammation by the poxvirus-derived pan-CC-chemokine inhibitor vCCI. Journal of Immunology (Baltimore, Md 1950), 165, 3418-3422. 

Thomas, M. S., Kunkel, S. L., and Lukacs, N. W. (2002). Differential role of IFN-gaimna-inducible protein 10 kDa in a cockroach antigen-induced model of allergic airway hyperreactivity Systemic versus local effects. J. Immunol. 169, 7045. 

Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ. AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Am J Pathol 2002 160(4) 1353-1360. 

Lukacs, N. W., Stricter, R. M., Warmington, K., Lincoln P., Chensue, S. W., and Kunkel, S. L. (1997). Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in murine allergic airway inflammation. J. Immunol. 158, 4398 1404. 

Basic Facts about Asthma. Patient s knowledge is improved. The anatomy of the lungs and bronchi and the manner in which inflammation can lead to airway hyperreactivity and bronchoconstriction should be explained in easy-to-understand terms. The link between allergic inflammation and bronchoconstriction should be clarified. Patients may be instructed to use two basic types of medications bronchodilatory (relievers) and anti-inflammatory (controllers) medications. Charts and airway models can clarify the programme. 

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