Coated PLGA nanoparticle

Santander-Ortega, M. I, Jodar-Reyes, A. B., Csaba, N., Bastos-Gonzalez, D., and Ortega-Vinuesa, J. L. (2006), Colloidal stability of Pluronic F68-coated PLGA nanoparticles A variety of stabilisation mechanisms, J. Colloid Interface Sci., 302(2), 522-529. 

Nafee N, Taetz S, Schneider M, Schaefer UF, Lehr CM. Chitosan-coated PLGA nanoparticles for DNA/RNA delivery effect of the formulation parameters on complexation and transfection of antisense oligonucleotides. Nanomed Nanotech Biol Med. 2007 3(3) 173-83. 

Semete B, et al. In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles. Toxicol Appl Pharmacol. 2010 249 158-65. 

In another study, PLGA nanoparticles coated with poloxamer 188 or poly-sorbate 80 enabled an efficient brain delivery of the drugs after intravenous injection. Pharmacological tests that used rats could demonstrate that therapeutic amounts of the drugs were delivered to the sites of action in the brain and showed the high efficiency of the surfactant-coated PLGA nanoparticles for brain delivery. ... 

W. Hasan, K. Chu, A. Gullapalli, S.S. Dunn, E.M. Enlow, J.C. Luft, S. Tian, M E. Napier, P.D. Pohlhaus, J.P. Rolland, J.M. DeSimone, Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer, Nano. Lett. 12 (2011) 287-292. 

Biodegradable polymer nanoparticles are PEG-coated poly(lactic acid) (PLA) nanoparticles, chitosan (CS)-coated poly(lactic acid-glycolic acid) (PLGA) nanoparticles, and chitosan (CS) nanoparticles. These nanoparticles can carry and... 

Coating of PLGA nanoparticles with the mucoadhesive CS improves the stability of the particles in the presence of lysozyme and enhanced the nasal transport of the encapsulated tetanus toxoid. Nanoparticles made solely of CS are stable upon incubation with lysozyme. Moreover, these particles are very efficient in improving the nasal absorption of insulin as well as the local and systemic immune responses to tetanus toxoid, following intranasal administration. 

Another major factor affecting the particle uptake is the nature of the material used to prepare the particles. Uptake of nanoparticles prepared from hydrophobic polymers seems to be higher than that from particles with more hydrophilic surfaces. Microspheres composed of polystyrene, poly(methylmethacrylate), poly(hydroxybutyrate), poly(D,L-lactide), poly(L-lactide), and poly(o,L-lactide-co-glycolide) were absorbed into the Peyer s patches of the small intestine, whereas those composed of ethyl cellulose, cellulose acetate hydrogen phthalate, and cellulose triacetate were not absorbed. Residual poly(vinyl alcohol) in the surface of PLGA nanoparticles significantly reduced the intercellular uptake, in spite of the smaller particle size." Similarly, poloxamer coating of... 

R. Saadati, S. Dadashzadeh, Z. Abbasian, H. Soleimanjahi, Accelerated blood clearance of PEGylated PLGA nanoparticles following repeated injections effects of polymer dose, PEG coating, and encapsulated anticancer drug, Pharm Res. 30 (4) (2013) 985-995. 

Cationic nanoparticles can also be obtained with cationic surfactants by incorporation during preparation or by incubation in a cationic surfactant. Didodecyldimethylammonium bromide (DMAB), dodecyltri-methylammonium bromide (DTAB), cetyltrimethylammonium bromide (CTAB), dimethyl(dioctyldodecyl)ammonium bromide (DODAB), benzyl-alkonium chloride and cetrimide are widely used as cationic surfactants for this purpose. PLGA nanoparticles which were coated with DMAB were developed for oral delivery of the anticancer drug paclitaxel. This formulation compared with intravenous administration of paclitaxel with cremo-phor showed an equivalent effect with a 50% lower dose of paclitaxel encapsulated in nanoparticles. ... 

Jeon SY, Park JS, Yang HN et al (2012) Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs. Biomaterials 33 (17) 4413 23... 

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