Clinical and pharmaceutical

W. F. Smyth (Editor), Electroanalysis in Hygiene, Environmental, Clinical and Pharmaceutical Chemistry Proceedings of a Conference Organized by the Electroanalytical Group of the Chemical Society, London, 17-20 April, 1979, (Analytical Chemistry Symposia Series, Vol. 2), Elsevier, Amsterdam, 1980. 

Kataoka, H. and Lord, H. L., Sampling and Sample Preparation for Clinical and Pharmaceutical Analysis. In Sampling and Sample Preparation for Field and Laboratory Fundamentals and New Directions in Sample Preparation, Pawliszyn, J., Ed., Vol. XXXVII, Elsevier Science, Amsterdam, Netherlands, pp. 779-836, 2002. 

Guzman, N. A. (2004). Immunoaffinity capillary electrophoresis applications of clinical and pharmaceutical relevance. Anal. Bioanal. Chem. 378(1), 37-39. 

Devices used for delivery of the drug (such as inhalers) are another area requiring an integrated clinical and pharmaceutical assessment for their performance, ease of use, and implications for safety and efficacy. 

Enantioanalysis is essential for substances with a chiral moiety from the body and pharmaceutical compounds. Utilization of EPMEs in clinical and pharmaceutical enantioanalysis improves the reliability of the analysis, shortens the time of analysis and minimizes its cost. 

Interest in the development of synthetic schemes and approaches to create molecular recognition elements has blossomed during the past half century for a number of reasons. In contrast to biologically based receptors, artificial mimics have the potential advantages of being less costly, more stable, and better able to withstand harsher conditions.7-12 Furthermore, synthetic methodologies can be used to create receptors for molecules for which an artificial receptor does not exist. These designer materials have enormous potential in catalysis, clinical and pharmaceutical applications, chemical sensors, separation science, and electronics.7-12... 

The above realities, along with the realization that large quantities of dilevalol would be needed quickly for the Toxicology, Clinical, and Pharmaceutical Development programs, led Research to propose a chiral synthesis for the initial supplies. The process identified was based on the use of a labetalol intermediate and analogous chemistry to that used in the subsequent manufacturing steps for labetalol. 

Wieten G, Meuzelaar HLC Haverkamp J (1984) Analytical pyrolysis in clinical and pharmaceutical microbiology In Odham G, Larsson L, Mardh PA (eds) Gas chromatography/mass spectrometry - applications in microbiology Plenum, New York 335-358... 

Current challenges in clinical and pharmaceutical studies are to explain the mechanism of cytotoxic activity of drugs, their transport into cancer cells, distribution and metabolism in the human body, interaction with proteins and with DNA... 

The element is used in ceramic industries and for the fabrication of semiconductors. Silicon-based polymers silicones polymeric chains containing alternately linked silicon and oxygen atoms) have wide application in industry as well as for clinical and pharmaceutical purposes. 

Medicinal products classified as cosmeceuticals may now be registered in Poland under a one-step procedure. Cosmeceuticals are cosmetics with properties that correct or modify physiological processes and treat or prevent disease. As medicinal products, they are considered to be supplemental to essential therapy and are mostly topically-applied products for dermatological conditions. Under the new registration procedure, documentation requirements are the same as for applications to register human medicines, namely pharmacological, toxicological, clinical and pharmaceutical/chemical documentation. 

Kataoka, H. New Trends in Sample Preparation for Clinical and Pharmaceutical Analysis, Trends Anal. Chem. 22(4), 232-244 (2003). 

In conclusion, reproducible analytical information can be obtained through both electrometric and spectrometric methods and also through immunoassay techniques, but only electrochemical methods can be successfully used for in vivo assays because electrochemical methods assure the best reproducibility of the analytical information for clinical and pharmaceutical analysis. 

To conclude this section, it is intriguing to observe how developments in instrumental analysis have led to an increase of sensitivity and a dramatic decrease of analysis time required by procedures based on isothermal distillation. The method of Conway, developed more than 35 years ago [4.11], still in use in clinical and pharmaceutical laboratories, requires many hours to perform an assay of a volatile species. The samples are kept in small, enclosed chambers containing the donor and the acceptor liquid, respectively, and after the diffusion process has reached equilibrium, the acceptor liquid is titrated. Gas-sensing probes, which operate on the principles of ion-selective electrodes, separated from the... 

The use of statistics in clinical and pharmaceutical settings is extremely common. Because the data are generally collected under experimental conditions that result in measurements containing a certain amount of error, statistical analyses, though not perfect, are the most effective way of making sense of the data. The situation is often portrayed as... 

The book presents a well-defined procedure for adding or subtracting independent variables to the model variable and covers how to apply statistical forecasting methods to the serially correlated data characteristically found in clinical and pharmaceutical settings. The standalone chapters allow you to pick and choose which chapter to read first and hone in on the information that fits your immediate needs. Each example is presented in computer software format. The author uses MiniTab in the book but supplies instructions that are easily adapted for SAS and SPSSX, making the book applicable to individual situations. 

Offers essential information for applying biostatistics to clinical and pharmaceutical research... 

Handbook of Regression and Modeling Applications for the Clinical and Pharmaceutical Industries, Daryl S. Paulson... 

Handbook of regression and modeling applications for the clinical and pharmaceutical industries / Daryl S. Paulson, p. cm. — (Biostatistics 18)... 

---