Foods Clindamycin

Tetracyclines. It is important to give the tetracyclines on an empty stomach tetracyclines are not to be taken with dairy products (milk or cheese). The exceptions are doxycycline (Vibramycin) and minocycline (Minocin), which may be taken with dairy products or food. The nurse should give clindamycin with food or a full glass of water. The nurse can give troleandomycin and clarithromycin without regard to meals. All tetracyclines should be given with a full glass of water (240 mL). 

Oral-Take with a full glass of water or with food to avoid esophageal irritation. Clindamycin absorption is not affected by food. 

Pharmacology Lincomycin and clindamycin, known collectively as lincosamides, bind exclusively to the 50 S subunit of bacterial ribosomes and suppress protein synthesis. Cross-resistance has been demonstrated between these 2 agents. Clindamycin is preferred because it is better absorbed and more potent. Pharmacokinetics Administration with food markedly impairs lincomycin (but not clindamycin) oral absorption. 

Food in the stomach does not interfere with the absorption of either clindamycin or lincomycin. Peak serum... 

Clindamycin is a more potent drug than the parent lincomycin. It possesses neuromuscular blocking activity and should not be used with other compounds having similar activity. The indications for clindamycin treatment are the same as those for lincomycin. It is absorbed more rapidly orally, and its absorption is not affected by the presence of food in the gastrointestinal tract as happens with lincomycin. 

Doxycycline is commonly used for moderate to severe acne vulgaris. It is more effective and produces less resistance than tetracycline. The initial dose is 100 or 200 mg daily, followed by 50 mg daily as a maintenance dose after improvement is seen. Doxycycline maybe given with food, but it is more effective when taken 30 minutes before meals. / Minocycline is also commonly used for moderate to severe acne vulgaris. It is more effective than tetracycline. It is dosed similar to doxycycline (100 mg/day or 50 mg twice daily) and on an indefinite basis in selected patients. Minocycline has the most reported adverse effects of the tetracyclines, some of which may be serious. Trimethoprim-sulfamethoxazole (or trimethoprim alone) is a second-line oral agent that may be used for patients who do not tolerate tetracyclines and erythromycin or in cases of resistance to these antibiotics. The adult dose is usually 800 mg sulfamethoxazole and 160 mg trimethoprim twice daily. Clindamycin use is limited by diarrhea and the risk of pseudomembranous colitis. 

Whereas oral hncomycin has a systemic availability of about 40%, which may be further compromised by food, clindamycin is absorbed from the gastrointestinal tract about 90-100%. Both are eliminated mainly by hepatic metabolism and biliary excretion. 

Clindamycin is absorbed rapidly from the gastrointeslini tract, even in the presence of food. It is available as ibt crystalline, water-soluble hydrochloride hydrate fhyclak. and the 2-palmitate c.stcr hydrochloride salts in oral dosigi forms and as the 2-phosphatc e.stcr in solutions for intramuv cular or intravenous injection. All forms arc chemically voi ssAwVvaw brj % aiic. 

Absorption Clindamycin is nearly completely absorbed following oral administration. Food does not affect absorption significantly. The of the antibiotic is 3 hours. 

The lincosamide class of antimicrobial drugs includes lincomycin, clindamycin, and pirlimycin two of these drugs—lincomycin and pirlimycin—are approved for use in food-producing species. Lincosamides are derivatives of an amino acid and a sulfur-containing galactoside. Lincomycin was isolated in 1962 from the fermentation product of Streptomyces lincolnensis subsp. lincolnensis. Clindamycin is a semi-synthetic derivative of lincomycin, and pirlimycin is an analog of clindamycin. 

The serum levels of lincomycin are markedly reduced (by up to two-thirds) if taken in the presence of food, but clindamycin is not significantly affected. Cyclamate sweeteners can also reduce the absorption of lincomycin. 

Reduced serum lincomycin levels due to the presence of food have been described in other reports, but the absorption of clindamycin is not affected. ... 

The food interaction with lincomycin is well established and of clinical importance. Lincomycin should not be taken with food or within several hours of eating a meal if adequate serum levels are to be achieved. An alternative is clindamycin, a synthetic derivative of lincomycin, which has the same antibacterial spectrum but is not affected by food. 

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Li S, Zhang Z, Cain A et al (2005) Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminate. J Agile Food Chem 53 32-37 Li L, Ge H, Seeram NP (2009) Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. J Agile Food Chem 57 7282-7287 Lim Y-H, Kim I-H, Seo J-J (2007) In vitro activity of kaempferol isolated from the Impatiens bal-samina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes. J Microbiol 45 473-477... 

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