Neuromuscular blocking activity

Neuromuscular blocking activity. Decoction of the seed oil, administered orally to adults of both sexes at a dose of 4.6 g/per-son, was active. A mixture of Piper longum, Zingiber officinale, Piper cubeba, Curcuma zedoaria, Juniperus communis, Cichorium intybus, Mentha arvensis. Commiphora mukul, and Sesamum indicum was given. Twenty five patients with laquwa (spastic facial paralysis) were treated with this mixture in divided doses of 4.6 g in 24 hours. Six grams of a decoction of Lavendula stoechas was also given in some cases. Sev-... 

NS-bis-alkyl-onium and S,S-bis-alkyl-onium compounds also have neuromuscular blocking activity [3—6]... 

Muir, T.C. and Lewis, J.J. (1959) Neuromuscular blocking activity in some NS-bis-onium compounds. /. Pharm. Pharmacol., 11 (Suppl), 91T—94T. 

Clindamycin is a more potent drug than the parent lincomycin. It possesses neuromuscular blocking activity and should not be used with other compounds having similar activity. The indications for clindamycin treatment are the same as those for lincomycin. It is absorbed more rapidly orally, and its absorption is not affected by the presence of food in the gastrointestinal tract as happens with lincomycin. 

As might be expected, ganglionic blockers produce a multitude of side effects because of the inhibition of both sympathetic and parasympathetic responses. Some adverse effects include gastrointestinal discomfort (nausea, constipation), urinary retention, visual disturbances, and orthostatic hypotension. At higher doses, they may even exhibit some neuromuscular blocking activity. These and other side effects may be quite severe in some patients. Fortunately, ganglionic blockers are usually not used for extended periods because the patient is placed on other antihypertensive drugs when the hypertensive crisis is resolved. 

Some semi-synthetic quaternary pyrrolizidine derivatives have marked biological activities. Ganglion- and neuromuscular-blocking activities were... 

DEPOLARIZING, NON-DEPOLARIZING CLINDAMYCIN, COLISTIN, PIPERACILLIN T efficacy of muscle relaxants Piperacillin has some neuromuscular blocking activity Monitor neuromuscular blockade carefully... 

DEPOLARIZING, NON-DEPOLARIZING VANCOMYCIN 1. t efficacy of these muscle relaxants 2. Possible risk of hypersensitivity reactions 1. Vancomycin has some neuromuscular blocking activity 2. Animal studies suggest additive effect on histamine release 1. Monitor neuromuscular blockade carefully 2. Be aware... 

Bolger, L., Brittain, R. T., Jack, D., Jackson, M. R., Martin, L. E., Mills, J., Poynter, D., Tyers, M. B. Short-lasting, competitive neuromuscular blocking activity in a series of azobis-arylimidazo-[l,2-Oi]-pyridinium dihalides. Nature 238, 354 (1972). 

Bisquaternary salts (70), prepared from the enantiomers of N-methylpavine and 1,10-di-iododecane, showed equal curarimetric neuromuscular blocking activity. ... 

It exerts a weak and feeble neuromuscular blocking activity which fails to produce signifieant muscle relaxation except imder deep ether anaesthesia. It has been found to potentiate the neuromuscular blockade caused by tubocurarine and to antagonize the action of decamethonium. Paradoxically, it has been used successfully to prolong and potentiate the relaxant effects of suxamethonium chloride. Besides, it has also been reported to decrease suxamethonium-induced muscular fasciculations. 

Reaction of d-tubocurarine virith methyl iodide affords metocurine iodide (see above), in virhich the tviro phenolic hydroxyl groups of d-tubocurarine are changed to the methyl ethers and the tertiary amine becomes quaternary. This agent is approximately fourfold more potent than d-tubocurarine in neuromuscular blocking activity. Like d-tubocurarine, it has a long duration of action and is eliminated (predominantly... 

Scientists examined the crude alkaloidal fractions derived from Shin-I (a traditional Sino-Japanese medicine) for the presence of neuromuscular blocking activity [41]. From the dried buds of M. salicifolia, three alkaloids, d-coclaurine (17), d-reticulin (18), and yuzirine (19) were found to reduce acetylcholine induced twitching of frog skeletal muscle. The active component of the purported antiallergy activity of Shin-I was identified as magnosalicin (20) [3]. Magnosalicin, a neolignan, was found in the chloroform extract of M salicifolia buds. 

Fig. (6 a). Influence of the position of the side-chains on the phenylene ring of bis(4-trimethylammoniobutyl)benzene (upper) and of the side-chain length of bis-trimethylammonium derivatives (lower) on neuromuscular blocking activity. The percentage inhibition of nerve-stimulated twitch response in mouse phrenic nerve-diaphragm muscle is plotted against the log concentration. The values represent means S.E.M. (n = 4-7). 

Fig. (6 b) Influence of side-chain length of bis-triethylaitiinoniuin derivatives on neuromuscular blocking activity. 

B. Quinidine and disopyramide also have anticholinergic activity quinidine has alpha-adrenergic receptor-blocking activity, and procainamide has ganglionic-and neuromuscular-blocking activity. 

The aminoglycoside antibacterials possess neuromuscular blocking activity. Appropriate measures should be taken to accommodate the increased neuromuscular blockade and the prolonged and potentially fatal respiratory depression that can occur if these antibacterials are used with conventional neuromuscular blocking drugs. 

The neuromuscular blockade due to suxamethonium (succinyl-choline) can be increased and prolonged by lidocaine, procaine and possibly procainamide. These local anaesthetics all have some neuromuscular blocking activity and may theoretically also enhance the block produced by competitive neuromuscular blockers. Increased toxicity occurred when mivacurium and prilocaine were given together for regional anaesthesia. 

Procainamide has been reported to increase the effects of suxamethonium in animals, increase muscle weakness in a myasthenic patient, and reduce plasma cholinesterase activity in healthy subjects. An animal study demonstrated potentiation of the neuromuscular blocking effect of tubocurarine by lidocaine alone and combined with antibiotics having neuromuscular blocking activity (neomycin or polymyxin B). ... 

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