Carbohydrate-protein linkage region

These conformations were subjected to a combined MD/EM refinement using the NOESY derived constraints as pseudoenergy functions. Families of conformations for the whole molecule were then constructed from the structures derived for each linkage. This procedure was demonstrated on a fragment from the carbohydrate-protein linkage region of connective tissue proteoglycans. 

We will illustrate our methodology using 0-3-D-galactopyranosyl -(1->4) 0-3 D-xylopyranosyl-(1->0)-L-serine (GXS), a fragment from the carbohydrate-protein linkage region of xylose/serine linked proteoglycans. 

MOLECULAR STRUCTURE OF THE CARBOHYDRATE-PROTEIN LINKAGE REGION FRAGMENTS FROM CONNECTIVE-TISSUE PROTEOGLYCANS... 

VIH. Structural Studies on the Carbohydrate-Protein Linkage Region. 215... 

X. Biosynthesis of Carbohydrate-Protein Linkage-Region Oligosaccharides. 228... 

Oligosaccharide Fragments Isolated from the Carbohydrate-Protein Linkage-Region of Dermatan Sulfate Proteoglycans 1... 

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R421 N. R. Krishna and P. K. Agrawal, Molecular Structure of the Carbohydrate-Protein Linkage Region Fragments from Connective-Tissue Proteoglycans , Adv. Carbohydr. Chem. Biochem., 2001, 56, 201... 

Rama Krishna N, Agrawal PK. Molecular structure of the carbohydrate-protein linkage region fragments from connective tissue proteoglycans. Adv Carbohydr Chem Biochem 2000 56 201-234. 

Funderburgh JL. Keratan sulfate biosynthesis. lUBMB Life 2002 54 187-194. Sugahara K, Yamada S, Yoshida K, de Waard P, Vliegenthart JF. A novel sulfated structure in the carbohydrate-protein linkage region isolated from porcine intestinal heparin. J Biol Chem 1992 267 1528-1533. 

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H18. Helting, T., and Rod n, L., The carbohydrate-protein linkage region of chon-droitin 6-sulphate. Biochitn. Biophys. Acta 170, 301-308 (1968). 

H19. Helting, T., and Rod6n, L., Biosynthesis of chondroitin sulfate. I. Galactosyl transfer in the formation of the carbohydrate-protein linkage region. J. Bid. Chem. 244, 2790-2798 (1969). 

Several fragments of the carbohydrate-protein linkage region... 

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