4-chloro-1-methoxy

The order NO2 > Cl, which is known for the reactions of nitro-activated aromatic compounds, is also found for pyridine and quinoline derivatives. In the reaction of 2-chloro-4-nitroquinoline with methoxide ion, only the 4-methoxide derivative is formed, as shown by gas-chromatography, whereas 2,4-dichloroquinoline yields a mixture of the isomeric chloro-methoxy derivatives in comparable amounts. ... 

Methane, nitio-, 55, 78 Methane, tnphenyl, 55,11 Methanesulfonyl chlonde, 55, 116, 120 Methyl chlonde, diphenyl- [Methane, chlo-rodiphenyl-], 55 94 Methyl ether, chloromethyl- [Methane, chloro-methoxy-], 55,94... 

Methane, chloro-methoxy- [Methyl methyl ether, chloro-], 55, 94 Methane, 4-( 1,1 -dimethylethyl)phenyl-... 

I4l6-Tii-0-benzoyl-[(S)-1,2-0-chloro(methoxy)methylene]-p-D-mannopyranose... 

The products produced by interaction of diazonium salts and iodides are unstable and liable to be explosive in the solid state. They are usually the triiodides, but monoiodides have been isolated under specific conditions from diazotised aniline and o-toluidine. Products prepared from diazotised o-, m- or p-nitroanilmes, m-chloro-, -methoxy-, or -methyl-aniline are too unstable to isolate, decomposing below 0°C. 

The use of trialkyl phosphates for dialkylation of anilines has been found applicable to naphthylamines and to a large number of anilines substituted in the ortho, meta, or para position by groups such as chloro, methoxy, and methyl and in the meta position by fluoroalkyl (author s laboratory). The reaction has been used to introduce ethyl and M-butyl as well as methyl groups by employing the appropriate phosphate esters. The reported yields range from 50% to 95%. 

A detailed study of the interaction of diaryl sulfides with AICI3 (unsubstituted and p-chloro, methoxy, and fluoro) at -60°C showed the corresponding thianthrene radical ions(H-) to have been formed. Bis (4-nitrophenyl)disulfide produced thianthrene radical ion(l-l-) itself. The... 

Acylation of (S)-2-pyrrolidinemethanol (1) with aroyl chlorides provides amides 2 which, when treated with base and iodomethane or chloro(methoxy)methane, furnish the corresponding methyl or methoxymethyl ethers 3. 

To a stirred solution at 0 C under nitrogen of 5 mmol of an (.S )-l -aroyl-2-pyrrolidinemcthanol in 25 mL of CII.C1, are added 1.21 g (15 mmol) of chloro(methoxy)methane. followed by 1.5 g (15 mmol) of triethylamine. After stirring at 25 CC the reaction mixture is washed with 10 mL of 1 % aq hydrochloric acid, sat. NaHCOj soln and brine. Drying over MgS04. filtration and concentration in vacuo furnishes an oil which is subjected to flash chromatography (silica gel, ethyl acetate). 

The chlorine atoms in dichloromethyleneamino tellurium pentafluoride were replaced by methoxide, when the tellurium compound and sodium methoxide in diethyl ether were kept at 20° for four days2. The products were dimethoxymethyleneamino and chloro(methoxy) methyleneamino tellurium pentafluoride. 

Alkylation of cyclohexanone enamines with methyl chloro(methoxy)acetate, followed by alkaline hydrolysis, affords the y-keto acid 30, which readily cyclizes to the unsaturated lactone 31 on treatment with hydrogen chloride in acetic acid (equation 20)40. 

SYNS BCME BIS-CME CHLORO(CHLORO-METHOXY)METHANE DICHLORDIMETHYLAETHER (GERMAN) s) m-DICHLORODIMETHYL ETHER (DO T) sym-DICHLOROiMETHYL ETHER DIMETHYL-1,T-DICHLOROETHER OXYBIS(CHLOROMETHANE) RCRA WASTE NUMBER P016... 

Chloro(methoxy)- and chloro(phenoxy)carbenes, which are generated from the diazirine precursors, behave as ambiphiles in additions to alkenes, exhibiting high reactivities toward both electron-poor and electron-rich olefins. Methoxy(phenyl)- and ferrocenyl(methoxy)methylenes have been transferred in a stereospecific manner from transition metal complexes of these species to electron-deficient alkenes. Irradiation of benzocyclobutanedione with UV light induces a rearrangement of the cyclic a-diketone to 17, which has been trapped by alkenes in good yields " . Thermolysis of 18 gives rise to nucleophilic dimethoxycarbene, which has been intercepted by electron-deficient olefins or by styrene derivatives. 

Woods treated with varying amounts of chloro, methoxy and phenoxy phosphazenes have been studied by IR spectroscopy and other techniques after pyrolysis all of which confirm... 

The reaction of methyl trichloromethyl ether with methyllithium, lithium iodide and cyclo-pentadiene gives anisole. It is formed by the rearrangement of the chloro(methoxy)carbene (or carbenoid) adduct... 

The reaction of chloro(methoxy)methyl tolyl sulfone with a base generates methoxy(4-tosyl)-carbene (carbenoid) which adds to 1,2-dimethoxyethene, straight chain and cyclic enol ethers or arylethenes to give 1-methoxy-l-tosylcyclopropanes. Concentrated (50%) aqueous potassium hydroxide with a catalytic quantity of 18-crown-6 or, in one case, butyllithium, was used as the base (see Houben-Weyl, Vol. El9b, pp 1730-1734). 

Several 1,2,4,6-thiatriazine 1,1-dioxides have been synthesized from other thiatriazine derivatives by nucleophilic substitution of 3- and/or 5-oxo, -thio, -chloro, -methoxy, -aryloxy, and -thiomethyl by ammonia or amines (84JHC1553 85TL11O1, 85TL1105). Other nucleophilic substitutions have been claimed to give derivatives such as 153 (83GEP3134145), 154 (76CB2107), and 155 (83GEP134141). 

Gross, H., and Seibt, H., a-Substituted phosphonic acid esters. Part 10. Synthesis of chloro(methoxy )meth-ylphosphonic esters and chloro(methylthio)methylphosphonic esters, J. Prakt. Chem., 312, 475, 1970. 

A carbene carrying both a donor and an electron-withdrawing substituent presents a new pattern of reactivity, often called ambiphilic, since such species can show both nucleophilic and electrophilic properties. Thus chloro(methoxy)carbene 4.222 has a low enough energy LUMO, making it electrophilic towards simple alkenes, and yet a high enough HOMO to make it able to react with electrophilic alkenes like methyl acrylate.443 None of the carbenes discussed above is capable of both of these reactions. 

Although MEEP-metal salt complexes show high ionic conductivities, these materials have undesirable creep properties at ambient temperatures, thus precluding their use in practical devices. To overcome this problem, one approach has been to synthesize dimensionally stable poly(phosphazenes) by crosslinking poly-[(chloro)(methoxy ethoxy ethoxy) phosphazene] with polyethylene glycol). If some of the chlorines in poly(dichlorophosphazene) are left unsubstituted after the initial reaction with the sodium salt of methoxy ethoxy ethanol, these can be reacted further with the difunctional poly(ethylene glycol)to afford crosslinked materials (Eq. 13 and Scheme 14) [204]... 

Of the. s-triazine derivatives, the chloro, methoxy and methylthio dialkylamino derivatives form one of the important groups of herbicides. According to the research work of Wolf el al., (1955) some of the s-triazine derivatives have fungicidal properties. In particular, those 2,4-dichloro-.s-triazines, which contain an arylamino or aryloxy group in position 6 have an important toxic action against phytopatogen fungi. One of these, 2,4-dichloro-6-(2-chloroanilino)-s-triazine,... 

O-Demethylation has been observed as well as, or instead of, nucleophilic displacement on reaction of 3,4,5-chloro/methoxy pyridazines and 4,5-chloro/methoxy-2-methyl-3(2//)-py-ridazinones with morpholine (e.g.. Scheme 63). Demethylation was observed at all ring positions, but usually adjacent to chlorine or a carbonyl group, and A -methylmorpholine was isolated, consistent with demethylation rather than hydrolysis. The demethylation can also occur with other primary and secondary amines such as diethylamine, butylamine, and piperidine, but not with pyrrolidine and aniline <87H(26)1 >. 3-Phenolic ethers of pyridazines are resistant to reductive cleavage of the aryl ether bond under the conditions of phase transfer catalytic hydrogenolysis <82T3775>. 

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