L-Chloro-2-methoxy-benzene

Chloromethoxybenzene Anisole, o-chloro- (8) Benzene, l-chloro-2-methoxy-... 

The following alkoxypyrazines have been prepared from the corresponding dichloropyrazines and alkoxide ions 2,3-dimethoxy-5,6-dimethyl(and diphenyl) (797) 2,3-dibenzyloxy (sodium benzyl oxide in benzyl alcohol at reflux for 24 hours (883)] [but 23-dichloropyrazine with sodium hydride and benzyl alcohol in xylene gave l,4-dibenzyl-2,3-dioxo-l,2,3,4-tetrahydropyrazine)(988)] 2-chloro-5-methoxy (838) 2,5-diethoxy-3,6-dimethyl (872) 2methanolic sodium methoxide refluxed for 2 h) 2,5-dimethoxy-3-phenyl (817) 2-chloro-5-methoxy(and ethoxy)-3,6-diphenyl (817) 2,5-dimethoxy-3,6-dimethyl (and diisopropyl) (844) 2,5-dimethoxy-3-isopropyl-6-methyl (methanolic potassium methoxide at reflux for 6 days) (844) 2(5)-s-butyl-3-chloro-6-ethoxy-5(2)-isobutyl (93) 2-chloro-6-methoxy (838, 883) 2,6-dimethoxy (reflux for 8h) (832) 2,6-diethoxy (reflux for 14 h) (883) 2-benzyloxy-6-chloro (1 equiv. of sodium hydride and benzyl alcohol in benzene at reflux) (832) 2,6-dibenzyloxy (5 equiv. of sodium benzyloxide in benzene at reflux gave 70%) (832) and 3,5-dimethoxy-2-methyl (535). 

Benzenamine [62-53-3], 122 Benzenamine, 2-methyl- [95-53-4], 86 Benzene, (2-bromoethyl)- [103-63-9], 82 Benzene, (bromomethyl)- [100-39-0], 78 Benzene, l-bromo-4-methyl- [106-38-7], 86 Benzene, chloro- [108-90-7], 86 Benzene, l-chloro-4-methyl- [106-43-4], 86 Benzene, l-(chloromethyl)4-methoxy-[824-94-2], 82... 

Benzene, bromo, 55, 51 Benzene, 1 -bromo4-chloro, 55, 51 Benzene, 4-bromo-l,2-dimethyl-, 55, 51 Benzene, l-bromo-4-fluoio-, 55, 51 Benzene, l-bromo-4-methoxy-, 55, 51 Benzene, 1-bromo-3-methyl-, 55, 51 Benzene, l-bromo-4-methyl- [Toluene, 4-bromo-], 55, 49... 

Benzaldehyde, 4-ethoxy-3-methoxy-, 56, 44 Benzaldehyde, 4-ethoxy-3-methoxy-, ethylene acetal, 56, 44 Benzaldehyde, 4-isopropyl-, 55,10 Benz[e ] anthracene, 58, 15, 16 BENZENAMINE, 4-bromo-Ar, V-dimcthyl-3-(tnfluoromethyl)-, 55, 20 Benzene, bromo-, 55,51 Benzene, 1 bromo-4-chloro-,55, 51 Benzene, 4-bromo-l, 2-dimethyl, 55, 51 Benzene, l-bromo-4-fluoro-, 55, 51 Benzene, 1 -bromo-4-methoxy-, 55,51 Benzene, l-bromo-3-methyl-, 55, 51 Benzene, 4-(cr/-buty 1-1-ethyl, 55, 10 Benzene, chemical hazard warning, 58, 168 Benzene, chloro-,56, 86 Benzene, l-ethyl-4-isopropyl-, 55, 10... 

Methyl-l-penten-3-one-l-ol 1 and glacial acetic acid in benzene was added to pyrrolidine to give 2-methyl-l-pen ten-1-[N-pyrrolidinyl]-3-one 2. Compound 2 when treated with oxalyl chloride and methanol was added, 3,5-dimethyl-2-methoxycarbonyl-4-pyrone 3 was produced. Treatment of compound 3 with sodium borohydride in methanol gives 3,5-dimethyl-2-hydroxymethyl-4-pyrone 4. Compound 4 was converted to 3,5-dimethyl-2-hydroxymethyl-4-pyridone 5 by heating compound 4 with aqueous ammonia in a sealed flask. Compound 5 was converted to 4-chloro-2-chloromethyl-3,5-dimethyl pyridine 6 by treatment with phosphorous oxychloride. Treatment of compound 6 with 5-methoxy-2-mer-captobenzimidazole in tetrahydrofuran gave 2-[2-(4-chloro-3,5-dimethyl pyridinyl)methylthio]-5-methoxy benzimidazole 7. When compound 7 was treated with potassium hydroxide in dimethyl sulfoxide containing methanol, 2-[2-(3,5-dimethyl-4-methoxypyridinyl)methylthio]-5-methoxy... 

Dipole moments (D) of some aminopyrazines have been determined as follows 2-amino-6-methoxy (3.08, benzene 3.42, dioxane) 2-amino-5-bromo-3-methoxy (2.94, benzene) 2-amino-3-chloro (1.86, benzene 2.26, dioxane) 2-amino-5-bromo-3-mercapto (2.22, dioxane) and 3-amino/l-oxide (3.43, dioxane) (749). 

Many amides have been prepared from pyrazinecarboxylic acid chlorides some are listed below with the relevant amines and references 2-chlorocarbonyl [MeNHj/ EtOAc (138) Me NH/EtOAc (138) BujNH etc/EtOAc (138) aniline/EtOAc (138, 1335) other aromatic and heterocyclic amines/EtOAc (138) sulfanilamide/ pyridine (1336) p-(2 -aminoethyl)benzenesulfonamide (1385) p-anisidine/benzene (1334) 4-hydroxypiperidine/benzene chloroform (1386) morpholine/DMF/20° (1387) 2-aminopyrimidine/benzene (1388) glycine/NaOH/ether (1201, cf. 1333, 1360)] 2-chlorocarbonyl-5-methyl [MeNHj/benzene (1337) MejNH/benzene (1337) 4-phenylpiperazine or diethanolamine/benzene-chloroform (1386) 2-chlorocarbonyl-3-phenyl (6-aminopenicillanic acid) (1024) 2-chloro-3-chloro-carbonyl (morpholine/benzene) (838) 2-chloro-5-chlorocarbonyl (NH4OH) (839) 2-chloro-6-chlorocarbonyl (Et2NH/benzene) (870, 1389) 2-chlorocarbonyl-5-hydroxy (aniline/benzene) (1055) 2-chlorocarbonyl-3-methoxy (morpholine/ benzene) (867) 2-chlorocarbonyl-5-methoxy (morpholine/benzene-chloroform) (1386) and 2-(l -chlorocarbonylethyI) (morpholine/benzene) (364). 

The following aromatic compounds have been detected by GLC in small amounts in Evernia prunastri (L.) Ach. benzene, toluene, isopropylbenzene, m-ethyltoluene, mesitylene, 1,2,3-trimethylbenzene, isobutylbenzene, bro-mobenzene, l,2-dimethyl-3-ethylbenzene, 1-chloro-2,4-dimethoxy-6-methylbenzene, a,p-dimethylstyrene, naphthalene, bis-(p-tolyl)-1,2-ethane, phenol, 2-chloro-3-methoxy-5-methylphenol, phthalic acid and N,N-dimethyl-p-toluenesulfonamide (Gavin and Tabacchi 1975), and a,a-dimethylstyrene,... 

Synonyms 1,1, -(l-Chloro-l-ethenyl-2-ylidene)trl8(4-methoxy-benzene) chlorotris(p-methoxyphenyl)ethylene Trade names TAGS... 

A soln. of 4-diloro-N-trifluoroacetylanthranilic acid and SOCl in dry benzene refluxed 12 hrs. 7-chloro-2-trifluoromethyl-4H-3,l-benzoxazin-4-one (Y 93%) dissolved with methyl 5-methoxy-2-methyl-2,3-dihydroindole-3-acetate in dimethyl sulfoxide, and heated 12 hrs. on a steam bath methyl l-(2-trifluoroacetamido-4-dilorobenzoyl)-5-methoxy-2-methyl-2,3-dihydroindole-3-acetate (Y 82%). F. e. s. D.R. Olson, W.J. Wheeler, and J.N. Wells, J. Med. Chem. 17, 167 (1974). 

Preparationbydemethylationof3, 4-dichloro-2,5-di-methoxy-4 -methylbenzophenone OH (SM) with boron tribromide in methylene chloride at 0° for 15-17 h (70-95%). SM was prepared by reaction of 3-chloro-4-methylbenzoic acid with 2-chloro-l,4-dime-thoxy-benzene in the presence of polyphosphoric acid at 60-70° for 6-7 h (40-83%) [1250],... 

Pertusaria cicatricosa By condensation of 2-benzyloxy-3-chloro-4-methoxy-6-methylbenzoic acid and l,3,5-tribenzyloxy-2-chloro-benzene with TFAA and subsequent debenzylation with BCI3 (196)... 

Friedel-Crafts methylation of methoxybenzene (anisole) with chloromethane in the presence of AICI3 gives a 2 1 ratio of ortho para products. Treatment of methoxybenzene with 2-chloro-2-methylpropane (terf-butyl chloride) under the same conditions furnishes only l-methoxy-4-(1,1-dimethylethyl) benzene (p-tert-butylanisole). Explain. (Hint Review Section 16-5.)... 

Oxidation of 4-methyl-2-tert-butylphenol (225, Scheme 57) by 2,3-di-chloro-5,6-dicyano-l,4-benzoquinone in methanol affords the dibenzofuran 228. The intermediate oxepinobenzofuran 226, as its valence isomer 227, undergoes nucleophilic attack by methanol and subsequent dienone-benzene rearrangement with the migration of the methoxy group. 

Previous work has shown that the electronic characteristics of the benzene substituent in triarylphosphine chlororhodium complexes have a marked influence on the rate of olefin hydrogenation catalyzed by these compounds. Thus, in the hydrogenation of cyclohexene using L3RhCl the rate decreased as L = tri-p-methoxyphenylphosphine > triphenylphosphine > tri-p-fluorophenylphosphine (14). In the hydrogenation of 1-hexene with catalysts prepared by treating dicyclooctene rhodium chloride with 2.2-2.5 equivalents of substituted triarylphosphines, the substituent effect on the rate was p-methoxy > p-methyl >> p-chloro (15). No mention could be found of any product stereochemistry studies using this type of catalyst. 

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